Session: FP40-Renin-Angiotensin-Aldosterone System/Endocrine Hypertension
Room 135 (Moscone Center)
Poster Board MON-725
Objective:To elucidate the behavior of plasma MMP-9 and MMP-2 activities in hypertensive children with 11β-HSD2 deficiency activity compared with hypertensive children with normal enzyme activity matched by BMI percentile
Design: Cross- sectional study.
Subjects and methods: Hypertensive (n=102) children (5-16 years old) were studied. Systolic and diastolic blood pressure indexes (SBPi & DBPi) were calculated using the observed blood pressure/percentile 50th(for gender, height and age). Fasting serum cortisol (F) and cortisone (E) concentration were measured by RIA and the 11β-HSD2 activity was estimated by F/E ratio. 11β-HSD2 deficiency activity was considered when F/E ratio ≥4.3 (mean +2 SD in 93 normotensive subjects (1)). Plasma MMP-9 and MMP-2 activities were evaluated by zymography. Their results were expressed as number of changes respect to the reference plasma used as internal control. Of these hypertensive children 18/102 (17.6%) had F/E ratio≥4.3 (Group A, n=18). They were selected and were compared with a group of hypertensive children with F/E ratio<4.3 (Group B, n=18) matched by BMI percentile. The results were expressed as median [Q1-Q3] and compared by Mann Whitney test.
Results: Group A and Group B showed similar age, 10.9 [7.7 – 12.9] vs 12.2 [10.3-14.1] years; P= 0.184). Group A had higher SBP index than Group B (1.24 [1.18–1.29] vs 1.14 [1.11- 1.18]; P <0.001); but they had similar DBP index (1.25 [1.12–1.37] vs 1.17 [1.06-1.23]; P=0.078). Plasma MMP-9 and MMP-2 activities were higher in Group A than Group B (2.87 [2.02–3.09] vs 1.97 [1.37-2.34]; P=0.0124and 1.97[1.7–2.34] vs 1.55 [1.02-1.70]; p=0.018, respectively
Conclusion: As far as we know, this is the first report showing an increase MMP-9 and MMP-2 activities in hypertensive children with high F/E ratio, suggesting that these patients have early and higher remodeling of the extracellular matrix.
Nothing to Disclose: AM, CC, HG, MA, CA, LB, RDB, CAL, CAC, LG, SL, CEF
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
See more of: Abstracts - Orals, Featured Poster Presentations, and Posters