Session: SAT 41-52-HPA Axis & Disease States
Poster Board SAT-41
Lean (BMI=20-25 kg/m2; n=19) and overweight/obese (BMI=27-35 kg/m2; n=17) men aged 50-70 years were allowed to prepare their own lunch at 12:00 pm using bread, margarine, cheese, processed meat (ham or chicken), tomato, cucumber, nuts, fruit bars and a fruit juice box drink. Records were made of foods consumed. Energy and macronutrient intake were determined using Foodworks (version 6.0; Xyris Software, QLD). Concentrations of cortisol were measured (by enzyme immunoassay) in samples of saliva collected every 15 min from 11:45 am to 2:00 pm with the exception of during lunch (12:15 pm) when no sample was collected.
Mean (±SEM) body weight and BMI were significantly higher in overweight/obese men compared to lean men (93.8±2.3 vs 69.7±1.6 kg and 30.6±0.6 vs 23.5±0.3 kg/m2, respectively; p<0.001 for both). Lean and overweight/obese men did not differ significantly in their energy intake (2895±245 vs 3015±235 kJ) or macronutrient intake (Protein: 27.2±2.1 vs 29.9±2.5 g; Carbohydrate: 65.2±6.4 vs 73.0±5.4 g; Fat: 37.2±4.3 vs 35.7±4.3 g, respectively; p>0.05 for all). For cortisol, repeated measures analysis of variance revealed a significant time*treatment interaction (p=0.008). Overweight/obese men responded to food intake with a significant elevation (51%) in salivary cortisol (time effect: p=0.005) whereas lean men did not have a significant elevation (5%) of cortisol (time effect: p=0.382).
While overweight/obese men had a significant cortisol response to food ingestion, lean men did not. If overweight/obese men have an elevated cortisol response every time they ingest food, they may be more susceptible to the development of stress-related disease.
Nothing to Disclose: AIT, SJT, ET, CAN, AJT, SUJ
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