Serum osteocalcin levels in girls with central precocious puberty

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 596-630-Pediatric Endocrinology
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-627
Young Jun Rhie*1, Yeon Joung Oh2, Joon Woo Baek3, Hyo-Kyoung Nam4 and Kee-Hyoung Lee4
1Korea University Ansan Hospital, Korea University College of Medicine, Ansan-si, Gyeonggi-do, South Korea, 2Hallym University Kangnam Sacred Heart Hospital, 3Korea University College of Medicine, 4Korea University College of Medicine, Seoul, South Korea
Objectives: Bone plays metabolic roles through osteocalcin (OC) when it is released into the systemic circulation in uncarboxylated form. Identified novel metabolic roles of OC include increasing insulin secretion and sensitivity, energy expenditure, reduction of fat mass and mitochondrial proliferation and functional enhancement. The onset of puberty is influenced by metabolic factors. This study was aimed to determine serum OC levels in girls with central precocious puberty (CPP) and to investigate the effects of OC on the onset of puberty. Methods: To diagnose CPP, Gonadotropin-releasing hormone (GnRH) stimulation test was performed in girls who show Tanner breast score ≥ 2 before the age of 8. Basal serum samples were obtained prior to GnRH injection. GnRH (0.1 mg) was administered intravenously for 1 minute and post-stimulation samples were taken at 30, 60, and 90 minutes after injection for measurements of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. Bone age was determined in all subjects. Serum OC levels of girls with CPP (n=30) and their age-matched controls (n=30) were measured. Results: Serum OC levels were significantly higher in CPP group compared with control group (76.8 ± 10.5 vs. 61.6 ± 15.1 ng/mL, p=0.001). Serum OC levels were correlated with peak LH levels during GnRH stimulation test (r=0.348, p=0.037), bone age (r=0.403, p=0.010) and bone age advance (r=0.323, p=0.042), but not related to age, height, weight and BMI. Conclusions: Serum OC seems to be associated with the onset of puberty leaving casual relations unresolved.

Nothing to Disclose: YJR, YJO, JWB, HKN, KHL

*Please take note of The Endocrine Society's News Embargo Policy at