Session: OR22-Male Reproductive Hormones: Effects on Fertility and Beyond
Room 104 (Moscone Center)
Methods In a prospective case control study from 2002 to 2005 at the Nice University Hospital, cord blood INSL3 (assessed by EIA) and testosterone (assessed by RIA) were measured and correlations with cord blood bisphenol A (assessed by RIA) and breast milk DDE, PCB 153, and mono- and dibutyl phthalates were calculated. These last were measured by gas chromatography coupled to mass spectrometry in 180 boys (52 cryptorchidic boys born after 34 weeks gestation: 26 transient and 26 persistent, as well as 128 controls matched for term, weight and time of birth
Findings INSL3 was decreased in the cryptorchidic boys (p=0.03), especially transient UDT (p=0.002), while testosterone was unchanged and LH was increased (p<0.056). In the whole population, LH correlated negatively with INSL3 (p=0.002). None of the Environmental Endocine Disrupors (EEDs) was significantly increased in the UDT group. However, in the whole population (n=180), BPA was inversely correlated with INSL3 (p=0.003).
Interpretation INSL3 is a major actor in testicular descent. It is decreased in the cord blood of cryptorchidic newborns and is a specific marker of impaired Leydig cell function associated with fetal exposure to EEDs. As a xenoestrogen, BPA can repress INSL3 gene expression. This is the first time that a direct link between fetal exposure to EEDs, decreased INSL3, and cryptorchidism has been established in humans. Fetal exposure to a cocktail of EEDs with estrogenic and antiandrogenic effects should be considered as one of the cofactors, associated with genetic susceptibility, contributing to this frequent, complex and multifactorial disease.
Nothing to Disclose: PF, NL, PC, MMP, PP, PF, KW, FSB
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