THE EFFECT OF CALPAIN-10 GENE POLYMORPHISM ON THE DEVELOPMENT OF TYPE 2 DIABETES MELLITUS IN TURKISH POPULATION

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 796-817-Diabetes Genetics & Epidemiology
Translational
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-808
Emre Arslan1, Leyla Acik2, Gulsah Gunaltili2, Goksun Ayvaz1, Alev E. Altinova1 and Metin Arslan*1
1Gazi University Faculty of Medicine, Ankara, Turkey, 2Gazi University Faculty of Sciences, Ankara, Turkey
The variations in the Calpain-10 gene have been suggested to be related with the susceptibility to type 2 diabetes mellitus (T2DM) in different populations. In this study, we investigated the relationship between single nucleotide polymorphism (SNP)-19, -44 and -63 in the Calpain-10 gene and the development of T2DM in Turkish population. A total of 211 subjects were recruited: 118 patients with the diagnosis of T2DM and 93 unrelated healthy subjects. There were no significant differences in the genotype and allele distribution of SNPs studied between the patients with T2DM and controls (p > 0.05) whereas the frequencies of 121 haplotype and 122/121 haplotype combination were found to be higher in patients with T2DM than those in controls (p < 0.05). No association was observed between the variations in the Calpain-10 gene and glycemic control and lipid parameters (p > 0.05). The SNP-19 insertion/insertion was significantly related with increased body mass index (BMI) in male diabetic patients (p < 0.05). In conclusion, present study indicates that 121 haplotype and 122/121 haplotype combination of SNP-19, -44 and -63 in the Calpain-10 gene are associated with the development of T2DM in Turkish patients.

Nothing to Disclose: EA, LA, GG, GA, AEA, MA

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm