Session: MON 818-841-Diabetes Pathophysiology & Complications
Poster Board MON-837
Materials and methods: From August 2011 to August 2012, 270 Type 2 diabetic patients (129 male, 141 female) entering the diabetes care center of Incheon St. Mary’s hospital were included in this study. Basic clinical information was required by a standardized questionnaire. Brachial-ankle PWV as a marker of stiffness of artery was measured and mean and maximal carotid IMT was evaluated by B-mode ultrasound. Platelet counts and MPV were measured using an automated blood cell counter. The fasting blood glucose levels, HbA1C and urine albumin/creatinine ratio(UACR) were also measured.
Results: The mean age of study population was 56.71±12years in men, 58.56±10.84years in women and the mean duration of diabetes was 7.95±7.89years and 7.71±7.13years, respectively. In men, MPV was significantly correlated with fasting glucose and HbA1c(r=0.325 and r=0.415, respectively, p=0.000). In women MPV was significantly correlated with HbA1c(r=0.323, p=0.000). Multivariable analysis identified that MPV levels were independently associated with HbA1c in men and women(p=0.000) but not diabetic vascular complications.
Conclusion: Our results suggested a close relationship between poor glycemic control and mean platelet volume(MPV) in type 2DM. But, we did not find a significant correlation between MPV and diabetic micro- and macrovascular complications.
Nothing to Disclose: EYM, SM, ESK, JHH
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