Mean Platelet Volume in Type 2 Diabetes Melllitus

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 818-841-Diabetes Pathophysiology & Complications
Basic/Clinical
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-837
Eun Yeong Mo*1, Sungdae Moon2, Eun sook Kim3 and Je ho Han3
1Catholic Univ, Incheon, South Korea, 2Catholic Univ of Korea, Incheon, South Korea, 3Catholic Univ, Incheon
Aims: Platelet activity and aggregation potential are essential components of thrombogenesis and atherosclerosis. The mean platelet volume(MPV), which is a marker of platelet size and platelet activity, can be conveniently measuring as part of whole blood count. It has been shown that MPV was significantly higher in diabetes mellitus. The aim of this study was to investigate the relationship among MPV, glycemic control and micro and macrovascular complications in type 2 DM without clinical cardiovascular disease.

 Materials and methods: From August 2011 to August 2012, 270 Type 2 diabetic patients (129 male, 141 female) entering the diabetes care center of Incheon St. Mary’s hospital were included in this study. Basic clinical information was required by a standardized questionnaire. Brachial-ankle PWV as a marker of stiffness of artery was measured and mean and maximal carotid IMT was evaluated by B-mode ultrasound. Platelet counts and MPV were measured using an automated blood cell counter. The fasting blood glucose levels, HbA1C and urine albumin/creatinine ratio(UACR) were also measured.

 Results: The mean age of study population was 56.71±12years in men, 58.56±10.84years in women and the mean duration of diabetes was 7.95±7.89years and 7.71±7.13years, respectively. In men, MPV was significantly correlated with fasting glucose and HbA1c(r=0.325 and r=0.415, respectively, p=0.000). In women MPV was significantly correlated with HbA1c(r=0.323, p=0.000). Multivariable analysis identified that MPV levels were independently associated with HbA1c in men and women(p=0.000) but not diabetic vascular complications.

Conclusion: Our results suggested a close relationship between poor glycemic control and mean platelet volume(MPV) in type 2DM. But, we did not find a significant correlation between MPV and diabetic micro- and macrovascular complications.

Nothing to Disclose: EYM, SM, ESK, JHH

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