Session: SUN 88-129-Acromegaly & Prolactinoma
Poster Board SUN-123
[Objective] In this study, we investigated longer term changes of renal function in patients with acromegaly after TSS.
[Patients and Methods] We studied 32 patients (M/F 16/16 age: 23-72 y.o) with acromegaly. All patients met the post-surgical remission criteria (nadir GH level <1ng/ml during 75g OGTT and normal IGF-I). The changes in eGFR of the patients during 5 years after TSS and relationships between eGFR and levels of GH and IGF-I was investigated.
[Results] Before TSS, median eGFR was 84.3 ml/min/1.73m2 (range: 55.7-151.3), and it was more than 90 ml/min/1.73m2 in 15 patients. Median eGFR significantly decreased to 75.4 ml/min/1.73m2 (P<0.05) in one year after TSS. The eGFR in 2, 3, 4, and 5 years after TSS were 75.2, 75.4, 70.4 and 76.0 ml/min/1.73m2, respectively, indicating that further change was not observed. Before TSS, there were no significant relationships between eGFR and serum GH and IGF-I levels. Moreover, there were no significant relationships between decrease in eGFR and decrease in GH and IGF-I levels after TSS.
[Conclusion] In patients with acromegaly, whose IGF-I levels were within normal range, eGFR decreased within one year after TSS but subsequent deterioration of renal function was not observed.
Nothing to Disclose: TM, NH, IF, KA, YI, AI
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