Diet with low glycemic index, low glycemic load dessert consumption decreases serum Advanced Glycated End Products concentrations in both overweight/obese children and adults undergoing nutritional intervention

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 338-354-Physiological Impacts of Endocrine Disrupting Chemicals
Basic/Translational
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-349
Sarantis Livadas*1, Antonia Dastamani2, Aphrodite Dikaiakos3, Aimilia Mantzou4 and George P. Chrousos5
1Unit of Endocrinology, Metabolism and Diabetes, Athens, Greece, 2Unit of Endocrinology, Metabolism and Diabetes,, Athens, Greece, 3Eugenideion Hospital, Athens University Medical School,, Athens,, Greece, 4Eugenideion Hospital, Athens University Medical School, Greece, 5First Department of Pediatrics, Athens, Greece
Introduction: Advanced Glycated End Products (AGEs) constitute an abundant endocrine disruptor with strong oxidative, proinflammatory, and proatherogenic properties. Serum levels of AGEs are highly associated with cardiovascular (CVD) manifestations in both diabetic and non-diabetic populations and provide prognostic information in CVD progress. Ingested AGEs enter the circulation from everyday food consumption, specifically from refreshments, sweets and heat-processed foods.

Aim of the study: To investigate the effect of consumption of foods with low Glycemic Index/Glycemic Load (GI/GL) on serum AGEs levels in overweight/obese children and adults who follow a dietary intervention program.

Patients: We studied 28 obese and overweight adolescent girls (10-14 years) with BMI ≥ 85th percentile and 37 adults (33 women, 4 men), mean age 42 years, with a mean BMI of 32kg/m2.

Methods: All study participants followed a hypocaloric diet (carbohydrates 45%, lipids 35%, proteins 20%) and, depending on their preference, they were divided into two groups: Group A (n=14 children, 19 adults), allowing the consumption of low GI/GL desserts 4 times/week, and Group B (n=14 children, 18 adults) allowing the consumption of one dessert once a week. Anthropometric characteristics, metabolic/hormonal profiles, as well as AGEs levels, were evaluated at the beginning of intervention and after 90 days of follow-up.

Results: BMI, glucose values and insulin resistance index (HOMA-IR) significantly improved in both children and adults at the end of the dietary intervention (p<0.05). In the total group, AGES levels were significantly lower at the end of the intervention (113,61±22,58 vs. 63,41±7,94µg/ml, p=0.019). In Group A, AGEs levels significantly improved compared to initial values (131,53±35,06 vs. 65,50±8,30 µg/ml, p=0.049), but this difference did not persist when analysis was carried out separately in children and adults. In Group B, AGEs levels were not modified significantly at the end of intervention in either the total group, or in the age subgroups.

Conclusions: A nutritional program offering low GI/GL desserts effectively helped achieve weight loss and significantly improved metabolic/hormonal profile, as well as decreased serum AGEs levels. Thus, this type of nutritional approach is recommended in either children or adults undergoing dietary intervention.

Nothing to Disclose: SL, AD, AD, AM, GPC

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm