QCT assessed bone loss during the trans- or post- menopausal period in Korean

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 248-267-Osteoporosis II
Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-250
Jo Eun Kim*1, Kyoung Min Kim2, Sujin Lee3, Won Jin Kim4, Kwang Joon Kim5, Yumie Rhee6 and Sung-Kil Lim7
1Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea, 2Yosei University College of Medi, Seoul, South Korea, 3Shinchong Dong Severance Hosp, Seoul, South Korea, 4Yonsei University College of Medicine, Severance Hospital, 5Severance Hospital, Seoul, South Korea, 6Yonsei Univ College of Medicine, Seoul, South Korea, 7Yonsei University College of Medicine, Seoul, South Korea
QCT (quantitative computed tomography) enables separate measurements of cortical and trabecular BMD, whereas cortical and trabecular areal BMD are measured in combination using DXA. Furthermore, QCT enables measurement of 3D geometric parameters directly, whereas DXA does not. Estrogen deficiency is one of the major cause of osteoporosis in the elderly.  The aim of this study was to assess the rate of bone loss by using QCT during the transition period from pre-menopausal- to post-menopausal age. Healthy 150 pretrans-, trans- or postmenopausal women aged 45 to 65 years were recruited and their volumetric bone mineral densities (vBMDs) were measured by QCT. For comparing the rate of bone loss, the subjects were divided into two groups by 10-year ages interval (45 to 55 years as pretrans-/trans-menopausal group and 56 to 65 years as postmenopausal group). The slopes of bone loss were calculated as Pearson correlations between age and vBMD after adjusting body mass index. Cumulative bone loss was 36.6 % at lumbar spine, and the rate of bone loss in the pretrans-/trans-menopausal group was faster than that of postmenopausal group (r=-0.305 vs. -0.192 ). Total amount of bone loss was 21.8% at femur neck, and the rate of bone loss was also greater in the pretrans-/trans-menopausal group (r=-0.356 vs. -0.144). Femur neck cortical thinning reached up to 31.8% during the transition period. Compared to the rate of bone loss in  postmenopausal women, the rate was greater during the pretrans-/trans-menopausal period. Taken together, a significant amount of bone loss as well as geometric change was observed during the premenopausal to postmenopausal transition period, and the rates were greater in the pretrans- to transmenopausal period than those of the postmenopausal women both at lumbar and femur.

Nothing to Disclose: JEK, KMK, SL, WJK, KJK, YR, SKL

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm