Session: SUN 88-129-Acromegaly & Prolactinoma
Poster Board SUN-103
Patients in the group 2 had significantly lower post-operative HOMA-IR (p=0.001) and pre-operative BMIs tended to be lower (p=0.053)than the patients of the Group1. In addition, post-operative HOMA-IR was negatively correlated with nadir GH level (r=-0.269, p=0.006). In contrast, there were no differences in peak glucose levels and other indexes between the two groups.
It has been reported that negative correlation of insulin resistance with nadir GH level upon the oral glucose tolerance test in healthy subjects. Our study suggests that GH secretion in patients with acromegaly having higher insulin sensitivity is not necessarily suppressed to lower than 0.4 ng/ml upon glucose challenge. Long-term follow-up of patients in the high group in the present study will help to validate the present criteria about biochemical remission of acromegaly.
Nothing to Disclose: NE, KM, HS, AT, NF, HN, YT, SY, YT
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