FP09-6 Understanding the Long Term Effect of Weight Gain Induced By Short Term Exposure of Antidepressants

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: FP09-Obesity: Physiologic Responses to Energy Balance Disruption
Bench to Bedside
Saturday, June 15, 2013: 11:00 AM-11:30 AM
Presentation Start Time: 11:25 AM
Room 307 (Moscone Center)

Poster Board SAT-677
Suhyun Lee*1, Claudio Alberto Mastronardi2, Rachel Li3, Gilberto J Paz-Filho4, Paul Smith5, Julio Licinio6 and Ma-Li Wong7
1John Curtin School of Medical Research, Australian National University, Canberra, Australia, 2Australian National University, Forrest, Australia, 3The John Curtin School of Medical Research, The Australian National University, Canberra, Australia, 4Australian National University, Acton, Australia, 5Canberra hospital, Canberra, Australia, 6The Australian National Univ, Canberra, Australia, 7The Australian National Univ, Canberra, ACT, Australia
Introduction Currently, antidepressants are among the most frequently prescribed classes of drugs. Over 164 million antidepressant prescriptions were issued in the USA in 2009, and 12.3 million antidepressant scripts were written for more than 1.6 million Australians in 2008. In the last decade, there has been a rise in antidepressant use and a concomitant rise in the rates of overweight and obesity. Significant weight gain (an increase of 7% or more over baseline weight) is associated with the use of most antidepressants. However, the pathophysiological mechanisms of this association are still poorly understood.

Methods Male Sprague-Dawley rats subjected to a novel paradigm, consisting of short-term exposure to recurrent restraint stress and antidepressants for 2 weeks, followed by long-term high-fat diet intake, were studied for 295 days. Body and organs weights, and behaviour were characterised.     

Results: During the post-stress recovery period, obesity prone rats treated with fluoxetine had increased body weight (R-FX) in comparison to the control group treated with saline (R-C) and non-restraint control group (NRCF) (R-FX vs R-C: 610.6 ±15.52vs503.4±10.75g, P <0.0001; R-FX vs NRCF: 610.6 ±15.52vs566.1±14.55g, P<0.05). Fluoxetine-treated animals also had heavier bones in comparison to control groups (R-C vs R-FX: 1.995±0.06vs2.39±0.07g, P<0.0001; NRCF vs R-FX: 1.996±0.03vs2.39±0.06g, P<0.0001). Furthermore, spleen weight in saline treated animals was significantly decreased, while antidepressant treated group did not differ when compared to non-restraint group (R-C vs NRCF: 0.640±0.03vs0.745±0.02, P<0.05). At the behavioural level, open field studies showed that antidepressant treated animals were significantly less anxious than saline treated animals during post-restraint period (R-C vs R-FX: 0.092 ± 0.005vs0.1139 ± 0.004 CD/TD ratio, P <0.01).

Conclusion Our study suggests that short-term exposure to stress and antidepressants leads to long-term body weight gain accompanied with increased bone and spleen weights. These findings may implicate different pathophysiological mechanisms in stress and antidepressant related obesity when compared to obesity that is solely diet-induced.

Nothing to Disclose: SL, CAM, RL, GJP, PS, JL, MLW

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

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