Session: SUN 88-129-Acromegaly & Prolactinoma
Poster Board SUN-124
Objective:To investigate the 3-dimensional characteristics of both soft tissue and bony parts of the face in patients in long-term remission of acromegaly.
Patients and methods: Sixteen patients in remission of acromegaly for at least 24 months (mean ± SD 105 ± 104) after successful transsphenoidal pituitary surgery (50% male, age 55.9 ± 10.7 years, BMI 29.3 ± 5.5 kg/m2) were compared to 16 age-, gender-, ethnicity-, and BMI-matched control subjects. A CBCT scan and 3D photograph of each individual were acquired and analyzed with the aid of 3D cephalometry according to the method of Swennen et al. (1).
Results: Compared to the matched control subjects, patients in long-term remission of acromegaly still showed striking differences in appearance. The following differences were the most impressive: Analysis of the bony tissue showed that patients have a longer mandible (median difference 4.80 mm, p=0.02), a longer maxilla (4.05 mm, p<0.01), increased anterior facial height (13.10 mm, p<0.01) and an increased face width (6.80 mm, p<0.01). Analysis of the soft tissues showed that patients have increased nose length (3.65 mm, p<0.01), an increased width of the nasal bridge (6.70 mm, p=0.02), an increased width of the mouth (3.45 mm, p=0.04) and an increased nasal tip protrusion (2.70 mm, p=0.01).
Conclusion:The 3-D fusion model is an attractive method to investigate craniofacial disproportions in patients with acromegaly. Significant craniofacial changes persist even after long-term remission. These data enable us to quantitatively study long term sequela of acromegaly and help to inform patients at the time of diagnosis. Longitudinal research is needed to establish to what extent craniofacial changes are reversible after remission and to what extent these changes are dependent upon the different treatment modalities.
Nothing to Disclose: SHPPR, MAEMW, TJJM, RHP, TX, JWAS, SJB, ARMMH, RTN
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