Cardiovascular Manifestations in Pre- and Postmenopausal Breast Cancer Patients

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 723-745-Lipids: Fatty Liver Disease & Lipodystrophies
Basic/Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-741
Nabila Roohi*1, Rabia Abid2 and Tahzeeb Fatima2
1Department of Zoology (Endocrinology), University of the Punjab, Lahore, Pakistan, 2University of the Punjab, Lahore, Pakistan
Background and aims: Breast cancer patients are at increased risk of death not only from cancer but also from other major competing causes of mortality, particularly, cardiovascular disease which is associated with altered lipid profile. Identifying the breast cancer patients at cardiovascular risk and provision of prompt and timely treatment would be helpful in reducing the morbidities and mortalities.

Subjects and Methods: Participants were age matched pre (n=44) and post (n=62) menopausal breast cancer patients, before and twenty days following five courses of chemotherapy (FAC regimn) and comparable controls including healthy, pre (n=24) and post (n=28) menopausal women. Fasting serum samples of controls and patients, at diagnosis and after chemotherapy, were processed for lipid profile. Statistical analysis was made by one-way ANOVA and Tukey’s Post Hoc multiple comparisons test using Graph Pad Prism (version 5.00).

Results: Serum total lipids, triglycerides,  cholesterol, and low-density lipoproteins elevated significantly (P<0.05), whereas, high-density lipoproteins indicated a significant decline (P<0.05), in pre- and postmenopausal breast cancer patients than comparable controls. The alterations were more pronounced in post- compared to premenopausal breast cancer patients. A similar trend, although less intensified, was observed in postmenopausal controls. Chemotherapy, in patients, could not restore the levels but further intensified the response, particularly, in postmenopausal breast cancer patients.

Conclusions: Evaluation of serum lipid profile could be considered as a vital clinical index for breast cancer diagnosis and prognosis and its associated cardiovascular risk. It is recommended that lipid profile should be regularly estimated in postmenopausal women presenting with breast cancer to avert the risk of cardiovascular disease in these patients.

Nothing to Disclose: NR, RA, TF

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm