Association of Vitamin D level with fat mass quantity and serum adipocytokines concentration in reproductive age women

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 238-262-Vitamin D Action, Deficiency & Disorders
Bench to Bedside
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-245
Tatiana Karonova*1, Elena Micheeva1, Olga Galkina2, Irina Nikitina1, Olga Belyaeva2 and Elena Grineva1
1Almazov Federal Heart, Blood and Endocrinology Centre, St.Petersburg, Russia, 2State Medical University n.a. I.P.Pavlov, St.Petersburg, Russia
Context: Recent studies suggested association of obesity with low vitamin D level. However, the mechanisms of this interlinks are still unknown.

Design and methods:We examined the interlinks between serum 25(OH)D and body composition and serum adiponectin and leptin levels in healthy late reproductive age women living in St. Petersburg, Russia.

Results: The study results showed Vitamin D insufficiency (lower than 50 nMol/L) in 61.3% and that 25(OH)D was inversely associated with obesity. We found that in obese women vitamin D level correlated with WC (r=-0.12, p<0.05), weight (r=-0.14, p<0.05), BMI (r=-0.12, p<0.05), and the amount of fat (r=-0.14, p<0.05). At the same time we saw that the obesity risk, was higher in women with 25(OH)D<50 nMol/L (OR 2.23[1.03-4.80]; CI95%) and with 25(OH)D<75 nMol/L (OR 1.86[0.88-3.95]; CI95%) than in subjects with Vitamin D level more than 75 nMol/L. We also came to the conclusion that leptin and adiponectin levels were associated with fat amount (r=0.43, p<0.001 and r=-0.26, p<0.01 accordingly). However, we did not find significant interlinks between 25(OH)D and adipocytokines concentration.

Conclusion: Our results showed high prevalence of vitamin D deficiency and interlinks between vitamin D level and obesity in healthy women population. Hence Low vitamin D level might possibly be a risk factor for obesity leading to development of insulin resistance and diabetes type 2.

(1) Holick MF, Mayo Clin Proc 2006; 353;373. (2) McGill AT et al., Nutrition Journal 2008; 1:5. (3) Wortsman J et al., Am J Clin Nutr 2000; 690:693. (4) Matsuzawa Y et al., Arterioscler Thromb  Vasc Biol 2004; 29:33. (5) Kull M et al., Intern Med J 2009: 256:258. (6) Blum M et al., Endocrine Reviews 2008; 90:94. (7) Adams JS, Hewison M., J Clin Endocrinol Metab 2010; 471:478.

Nothing to Disclose: TK, EM, OG, IN, OB, EG

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