Session: MON 515-547-Female Reproductive Endocrinology
Poster Board MON-529
[Methods]Experiment 1:female rats were treated with OVX or sham operation (Sham) and stress responses were compared between these two groups. Stress was induced by LPS, and then anorectic response, hypothalamic IL-1beta and TNF-alpha mRNA, and serum leptin level were measured. Experiment 2:Either estradiol and progesterone (EP) or Vehicle (Veh) was acutely injected in OVX female rats, and then stress responses were compared as like as Experiment 1.
[Results]Experiment 1:Body weight in OVX rats was heavier than that in Sham rats. OVX rats exhibited an increased anorectic response, higher serum lepitn level and greater increase of hypothalamic IL-1beta mRNA expression compared with Sham rats. Experiment 2:There was no differences between OVX-EP rats and OVX-Veh rats in the anorectic response, serum lepitn level and hypothalamic IL-1beta mRNA.
[Conclusion]Stress responses to immune stress were increased in OVX rats. Indirect action of gonadal steroid deficiency, such as obesity, might be related in this alteration.
Nothing to Disclose: TI, TM, RK, GG, MI
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