Session: MON 758-775-Beta Cells, Glucose Control & Complications
Poster Board MON-775
Methods: Whole room indirect calorimetry to assess 24h EE was done during 5 different diets in 11 subjects (8M/3F; 4C/3AA/3NA/1H; age 42±9yrs; % body fat 31±10%; 24h EE 1992±271; TG 95±59 mg/dl), all with normal glucose regulation as assessed by a 75g oral glucose tolerance test. Body composition was determined by DXA. The 5 diets were: fasting; eucaloric (50% mixed CHO, 20% PRO, 30% F); and three high CHO diets with 200% energy requirements (75% simple (CSS), complex (CCC), or mixed (CM) CHO, 20% PRO, 5%F). There was a 3 day, weight maintaining period in between dietary interventions. TG and insulin concentrations were drawn before and after the CCC and CSS diets.
Results: Compared to 24h EE during energy balance, 24h EE increased by 12.7±5.7% with the CM overfeeding diet (P<0.001). There were no differences in the increase in 24h EE, diet related EE, or respiratory quotient (a proxy for the ratio of CHO to lipid oxidation) between the three high CHO diets. However, sleeping EE was higher in the CSS diet compared with the CCC diet (Δ=147; P = 0.03), as was the percent increase in sleeping EE over measures in energy balance (17.1±7.0 v 7.6±9.0%; P=0.02). Comparing the CCC diet with the CSS diet, both the changes in fasting insulin (Δ= 2.7±3.3 v 0.1±2.3 μIU/ml; P=0.006) and the changes in TG (Δ=32±18 v 11±25 mg/dl; P=0.01) were greater the morning after the CCC diet. Differences in the TG response to overeating were largely determined by FFM (β=2.2 mg/dl; P<0.001) and FM (β=1.0 mg/dl; P=0.04).
Conclusion: When caloric intake of high CHO diets exceeds energy needs, the overall increase in 24h EE is similar regardless of the CHO source. However, the increased TG and insulin concentrations observed the morning after the CCC diet may indicate ongoing processing of these CHO, and that our time frame of 24h was not long enough to capture the full EE response to this diet.
Nothing to Disclose: SMB, MI, MH, JK, MST
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