Characterization of insulin resistance and insulin sensitivity in a Qatari population

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 677-696-Obesity Physiology & Epidemiology
Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-680
Mohamed Elrayess*1, Mashael Aljaber2, Aysha Ahmad Bakhamis2, Nelson Ndubuisi Orie3 and Mohammed Alsayrafi2
1ADLQ, Doha, Qatar, 2Anti Doping Lab Qatar, Doha, Qatar, 3ADL Qatar, Doha, Qatar
Background and objectives: Obesity and associated co-morbidities constitute a major health problem in Qatar. Increased obesity prevalence, especially when characterised by an early onset, has rendered a high proportion of the Qatari population insulin resistant (IR), and increased their risk of type II diabetes and cardiovascular disease. However, a sub-set of individuals maintain insulin sensitivity (IS) despite their obesity. Objectives of this study were to characterise components of IR/ IS obesity in a Qatari population.

Methods: Non-diabetic morbidly obese Qatari subjects (n=42) awaiting weight reduction surgery and age-matched healthy lean/overweight volunteers (n=14) were recruited. Following anthropometric measures recording, blood lipids, glucose, insulin and adipokines were determined before and 3 months after surgery. Both the lean/overweight and the obese subjects were dichotomised into IR and IS groups based on their HOMA index (fasting plasma glucose < 6.8 mmol/l and insulin levels < 6.5 miU/ml).

Results: In all subjects (n=56, 13 males/43 females, 30.5+/-7.5 years old, BMI of 37.5+/-11 kg/m-2) obesity was associated with significant elevations in leptin, CRP, systolic blood pressure, triglyceride, fasting blood glucose, insulin and HOMA. In the obese group, the prevalence of IS was 14% associated with lower fasting blood glucose, insulin and HOMA and a higher HDLC compared to IR group, despite similar age and BMI. In the lean/overweight group, the prevalence of IS was 28%, showing significantly lower blood pressure compared to the IR group. Following surgical weight loss, both IR and IS groups showed significant BMI reduction (42 kg/m 2 vs 36 kg/m 2, p=0.04), while only the IR group showed reduction in insulin (18 miu/ml vs 8 miu/ml, p=0.02), HOMA (4.1 vs 1.9, p=0.02) and leptin (71 ng/ml vs 28 ng/ml, p=0.03).

Conclusions: Surprisingly in this study, lean/overweight young Qatari subjects were already significantly IR. As expected in obesity, leptin, blood pressure, inflammatory markers, lipids and IR were elevated. Weight loss was an effective remedy for the IR but with no concomitant improvement in either dyslipidemia or hypertension in this population. The results of this study are being confirmed in a larger Qatari cohort.

Nothing to Disclose: ME, MA, AAB, NNO, MA

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm