The association of puberty with cardiometabolic risk factors in Afro-Caribbean children

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 596-630-Pediatric Endocrinology
Clinical
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-605
Michael S Boyne*1, Minerva Thame1, Clive Osmond2, Raphael A Fraser1, Leslie A Gabay1, Carolyn Taylor-Bryan1 and Terrence E Forrester1
1The University of the West Indies, Kingston, Jamaica, 2University of Southampton, Southampton, United Kingdom
Context: An earlier onset of puberty is associated with increased cardiometabolic risk in later life.  It is not clear if this is independent of adiposity or faster rates of childhood growth.

Objective:To investigate the correlation of the stage of puberty with cardiometabolic risk factors in Afro-Caribbean children.

Design:Observational study in a birth cohort (the Vulnerable Windows Cohort Study).

Measurements: Anthropometry was measured at birth, at 6 weeks, 3 monthly to 2 years and then every 6 months. Tanner staging for puberty started at age 8 years and was done every 6 months. At mean age 11.5 ± 1.3 years, fasting glucose, insulin, HOMA-IR, lipids and blood pressure were measured.  Multivariate analyses were done with 140 girls and 119 boys who had complete data. We defined growth as the change in height and BMI from birth to age 8 years.

Results: In boys, more advanced puberty (i.e. pubarche and testicular size) was associated with lower HDL-C, higher systolic blood pressure and higher HOMA-IR (P-values ≤ 0.05), but not after adjusting for current BMI or prior rate of growth. In girls, more advanced puberty (i.e. age at menarche and breast development) was associated with higher fasting glucose even after adjusting for current BMI and prior growth (β = -0.30; P ≤ 0.001 and β = 0.21; P = 0.04 respectively).  More advanced pubarche was associated with systolic blood pressure even after adjusting for current BMI and prior growth (β = 0.18; P= 0.02).

Conclusion:  More advanced puberty in Afro-Caribbean children is associated with markers of cardiometabolic risk. However, in boys this effect may be mediated by current body size.  In girls, this effect may be independent of current size and prior growth.

Nothing to Disclose: MSB, MT, CO, RAF, LAG, CT, TEF

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm