FP07-6 Serum 25-Hydroxyvitamin D, Mammographic Density and Breast Biopsy Results

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: FP07-New Players in Hormonal Control of Breast & Prostate Cancer
Basic/Translational
Saturday, June 15, 2013: 11:00 AM-11:30 AM
Presentation Start Time: 12:15 PM
Room 206 (Moscone Center)

Poster Board SAT-292
Monika E Schmidmayr*1, Johanna Lohmaier2, Loreen Richter2, Peter Luppa3, Almut Artmann4, Tibor Schuster5, Marion Kiechle6 and Vanadin Regina Seifert-Klauss7
1Tech Univ Muenchen, Munich, Germany, 2Technische Universitaet Muenchen, 3Technische Universitaet Muenchen, Munich, 4Praxis fuer Brustgesundheit, Munich, 5Technische Universitaet, Munich, 6Technische Universitaet Muenchen, Munich, Germany, 7Frauenklinik der TU Muenchen, Munich, Germany
Introduction

Vitamin D deficiency has been linked to higher grade breast tumors, thereby possibly affecting prognosis in breast cancer. Mammographic density is an established risk factor for breast cancer, while high density breast tissue may also delay diagnosis. The association of serum vitamin D and mammographic density has not been studied prospectively in a sufficiently large sample to date.

Methods

In this cross sectional study women with a clinical indication for mammography were recruited for a standardized interview on reproductive history, risk factors for breast cancer, diet, activity and chronic diseases. Serum 25-OH-vitamin D (sVD), calcium, phosphate and creatinine were measured and breast density by ACR classification documented. Patients with >= BIRADS IV received a breast biopsy.

Results

A significant difference in sVD was found between women with ACR 3 vs. ACR4 (p = 0.04) after multivariate adjustment for other risk factors, but not when comparing ACR 1 or 2 with ACR 4. Out of 1090 recruited women, 111 (10%) were biopsied, 53 (4.9%) were diagnosed with DCIS or invasive carcinoma. In a 1:2 matching analysis, matching criteria were age (+/- 5years), BMI (+/- 2kg/m²), menopausal status, family history, vitamin D or hormone intake. Patients with carcinoma or DCIS had mean sVD values of 16.1ng/ml vs. 16.7ng/ml in the control group (n=106). 96% of all women were vitamin D deficient. Regression analysis showed a non-significant 13% risk reduction for malignancy per 10ng/ml increase of sVD (OR 0.87, 95% CI 0.51-1.47, p=0.602).

Conclusion

Low serum vitamin D may independently influence very high breast density, thereby reducing mammographic sensitivity and increasing the risk of higher grade tumors.

· Bérubé et al.: Vitamin D, calcium, and mammographic breast densities. Cancer Epidemiology, Biomarkers & Prevention 2004;13(9): 1466-72  Greenwald et al.: Micronutrients in cancer chemoprevention. Cancer Metastasis Rev. 2002;21: 217-30  O'Kelly et al.: Vitamin D analogs and breast cancer. Recent Results Cancer Res. 2003;164: 333-48

Nothing to Disclose: MES, JL, LR, PL, AA, TS, MK, VRS

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: Bavarian Health Ministry
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