Session: FP07-New Players in Hormonal Control of Breast & Prostate Cancer
Room 206 (Moscone Center)
Poster Board SAT-292
Vitamin D deficiency has been linked to higher grade breast tumors, thereby possibly affecting prognosis in breast cancer. Mammographic density is an established risk factor for breast cancer, while high density breast tissue may also delay diagnosis. The association of serum vitamin D and mammographic density has not been studied prospectively in a sufficiently large sample to date.
In this cross sectional study women with a clinical indication for mammography were recruited for a standardized interview on reproductive history, risk factors for breast cancer, diet, activity and chronic diseases. Serum 25-OH-vitamin D (sVD), calcium, phosphate and creatinine were measured and breast density by ACR classification documented. Patients with >= BIRADS IV received a breast biopsy.
A significant difference in sVD was found between women with ACR 3 vs. ACR4 (p = 0.04) after multivariate adjustment for other risk factors, but not when comparing ACR 1 or 2 with ACR 4. Out of 1090 recruited women, 111 (10%) were biopsied, 53 (4.9%) were diagnosed with DCIS or invasive carcinoma. In a 1:2 matching analysis, matching criteria were age (+/- 5years), BMI (+/- 2kg/m²), menopausal status, family history, vitamin D or hormone intake. Patients with carcinoma or DCIS had mean sVD values of 16.1ng/ml vs. 16.7ng/ml in the control group (n=106). 96% of all women were vitamin D deficient. Regression analysis showed a non-significant 13% risk reduction for malignancy per 10ng/ml increase of sVD (OR 0.87, 95% CI 0.51-1.47, p=0.602).
Low serum vitamin D may independently influence very high breast density, thereby reducing mammographic sensitivity and increasing the risk of higher grade tumors.
Nothing to Disclose: MES, JL, LR, PL, AA, TS, MK, VRS
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