INFLUENCE OF LEAN MASS AND ADIPOKINES UPON BONE MASS IN YOUNG SURVIVORS OF CHILDHOOD ACUTE LYMPHOCYTIC LEUKEMIA

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 690-701-Obesity Pathophysiology
Translational
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-700
Adriana Aparecida Siviero-Miachon*1, Angela Maria Spinola-Castro1, Maria Lucia de Martino Lee2, Antonio Ramos Calixto3, Bruno Geloneze3, Marise Lazaretti-Castro1 and Gil Guerra-Junior3
1Federal University of Sao Paulo - UNIFESP/EPM, Sao Paulo, Brazil, 2Pediatric Oncology Institute - IOP/GRAACC, Sao Paulo, Brazil, 3State University of Campinas - UNICAMP, Campinas, Brazil
Background: Fat accumulation can affect bone through multiple mechanisms including the direct effect of adipokines or indirectly through the state of chronic inflammation and cytokines (1-3). Yet the relationship between fatness, lean mass and bone mass has not been fully understood (2). Bone mass may be impaired in survivors of childhood acute lymphocytic leukemia due to the disease itself, host characteristics, therapy (glucocorticoids and methotrexate), hormonal deficiencies (4-7), as well as changes in body composition (8-10). Thus, the aim of this study was to evaluate the effect of body composition and adipokines on bone mass in young survivors of acute lymphocytic leukemia. Methods: A cross-sectional study of 56 acute lymphocytic leukemia survivors, chronological age between 15 and 24 years, 44.6% received cranial radiotherapy (18 to 24 Gy), assessed according to body fat mass, bone-free lean mass and bone mineral density (dual energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue and adipokines, evaluated by a multiple regression analysis. Results: Total body, lumbar spine L1-L4 and femur bone mineral density were positively correlated with lean mass (multiple regression; p < 0.050). Cranial radiotherapy did not influence bone mass. Visfatin positively correlated, and leptin-to-adiponectin ratio and total abdominal adipose tissue negatively correlated with cortical bone (multiple regression; p < 0.050). Bone mineral density was at the inferior limit of normality in 25% of patients in total body, and 32.1% at the lumbar spine. There were no fractures during or following the completion of therapy. Conclusions: In young survivors of acute lymphocytic leukemia, lean mass was positively correlated with bone mass, and this effect has not been described in this group of patients yet. Visfatin and leptin-to-adiponectin ratio have played a role, to date unknown, in the complex relationship between body composition and cortical bone. The assessment of body composition along with bone mass is of extreme importance given their close integration in survivors of acute lymphocytic leukemia.

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Nothing to Disclose: AAS, AMS, MLDML, ARC, BG, ML, GG

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: This work was supported by grants from the Sao Paulo State Research Foundation - FAPESP (no 06/06162-9 to G.G-J.).