THE ACTIVITY OF LEPTIN IN NON OBESE CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 649-675-Central Regulation of Appetite & Feeding/GI Regulatory Peptides
Bench to Bedside
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-661
Izabela Maciejewska-Paszek1, Andrzej Siwiec2, Elzbieta Grochowska-Niedworok3, Lechoslaw Dul4, Anna Gruenpeter2 and Tomasz Irzyniec*5
1Medical University of Silesia, Katowice, Poland, 2The John Paul II Pediatric Center, Sosnowiec, Poland, 3Medical Univesity of Silesia, Katowice, Poland, 4Medical University of Silesia, Katowice, 5Medical University Of Silesia, MSW Hospital Katowice, Katowice, Poland
Background: Leptin regulates the organisms immune response, therefore its level decrease by adipose tissue reduction or nutritional restrictions may cause immunity disorders and contagious diseases hazard increase. Juvenile idiopathic arthritis (JIA) is a chronic joints disease, starting before the age of 16 and leading to chronic changes in motor organs. Due to improper anti-inflammatory mechanisms functioning during the rheumatic diseases, a spreadover macrophages and T lymphocytes activation occurs, which causes pro- and anti-inflammatory factors balance disruption.  Aim: The aim of the study was to assess the leptin concentration (L), in serum [ng/ml] of the 42 children with JIA and 28 healthy subjects (IC). All ill children were treated with non-steroidal anti-inflamatory drug (methotrexate). Patients and methods: The examined children (BMI<23 kg/m2) were divided into two subgroups:  IA (7 and 18 - mean 13 years old) n=22 consisted of children with longer (51-148 months), and  IB-(4 and 17 mean 10 years) with shorter disease period (2-18 months)-n=20. In all children body mass index (BMI) was calculated [kg/m2]. The relation between leptin concentration diversification per BMI unit (L/BMI), for ill and healthy children has been proven. Results: Leptin serum concentration were higher in patients with longer disease period L-LA Me: 5,85 ng/ml (min 1,24 max 37,5) as compared to healthy controls L-IC Me: 2,85 (2,4 and 3,74)  respectively - p=0,04.  Also leptin concentration diversification per BMI unit L-IA/BMI-IA were higher in this group of patients  Me:  0,33 (min 0,09 max 1,76) then in healthy children L-IC/BMI-IC 0,15 ± 0,01 (mean ± SEM) p=0,01.  Conclusion: Non obese patients with juvenile idiopathic arthritis with longer disease period had higher concentration of leptin, than healthy children.

Nothing to Disclose: IM, AS, EG, LD, AG, TI

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm