Non alcoholic fatty liver disease: A novel risk factor for the development of type 2 diabetes in childhood?

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 776-795-Cardiometabolic Risk & Vascular Biology
Clinical
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-776
Carolina Loureiro1, Carmen Campino2, Alejandro Martínez-Aguayo3, Marlene Aglony2, Carolina Avalos3, Lilian Bolte3, Rodrigo Bancalari2, Cristian A Carvajal2, Carlos E Fardella2 and Hernan Garcia Bruce*4
1Pontificia Universidad catolica de Chile, Santiago, 2Pontificia Universidad Catolica de Chile, Santiago, Chile, 3Pontificia Universidad Católica de Chile, Santiago, Chile, 4Pontificia Universidad Catolic, Santiago, Chile
Non alcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance (IR) and increased type 2 diabetes (T2D) risk. The physiopathology of these interactions remains unclear in pediatrics population. Alanine aminotransferase (ALT) is a recognized biochemical marker of NAFLD actually used as screening of this disease.

Objective: To estimate the associations between (ALT) with IR and endothelial inflammation parameters.

Patients and Method: 348 subjects (52.7% females) between 4.9 - 15.6 years old were studied. Fasting blood samples was obtained to determinate: ALT, aspartate aminotransferase (AST), glycaemia, insulin, lipid profile, high sensitive PCR (hsPCR), tumoral necrosis factor-α (TNF-α), interleukin-6 (IL-6) and adiponectin (A). HOMA-IR, QUICKI and HOMA-β were calculated. Variables were log10 transformed before Pearson correlations analyze.

Results: ALT levels were positively correlated with BMI-SDS (r= 0.335; P<0.0001), waist/ height ratio (r= 0.358;  P<0.0001), insulin (r= 0.33; P<0.0001), HOMA-IR (r= 0.33; P<0.0001), HOMA-β (r= 0.26; P<0.0001), TG/HDL-c (r= 0.2; P<0.0001), hsPCR (r=0.3; P<0.0001); and inversely correlated with QUICKI (r= -0.25; P<0.0001) and adiponectin (r= -0.113; P=0.03). No correlation between ALT with: glycaemia (P=0.60), TNF-α (P=0.14) and IL-6 (P=0.82) was found.

Conclusion: Our study demonstrated that ALT was significantly correlated with markers of IR and endothelial inflammation, all of them recognized as risk parameters of pre diabetes stage. Therefore, we suggest the measurement of ALT as a marker of NAFLD should be part of the evaluation of all obesity children, mainly those with other cardiometabolic risk factors, since it could predict later development of T2DM.

Nothing to Disclose: CL, CC, AM, MA, CA, LB, RB, CAC, CEF, HG

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: FONDEF D08i1087, FONDEF IDeA CA12i10150, FONDECYT 1100356 & 1130427 & IMII P09/016-F. CAC is PhD fellows from Comision Nacional y Científica de Chile (CONICYT). 
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