Session: MON 776-795-Cardiometabolic Risk & Vascular Biology
Poster Board MON-776
Objective: To estimate the associations between (ALT) with IR and endothelial inflammation parameters.
Patients and Method: 348 subjects (52.7% females) between 4.9 - 15.6 years old were studied. Fasting blood samples was obtained to determinate: ALT, aspartate aminotransferase (AST), glycaemia, insulin, lipid profile, high sensitive PCR (hsPCR), tumoral necrosis factor-α (TNF-α), interleukin-6 (IL-6) and adiponectin (A). HOMA-IR, QUICKI and HOMA-β were calculated. Variables were log10 transformed before Pearson correlations analyze.
Results: ALT levels were positively correlated with BMI-SDS (r= 0.335; P<0.0001), waist/ height ratio (r= 0.358; P<0.0001), insulin (r= 0.33; P<0.0001), HOMA-IR (r= 0.33; P<0.0001), HOMA-β (r= 0.26; P<0.0001), TG/HDL-c (r= 0.2; P<0.0001), hsPCR (r=0.3; P<0.0001); and inversely correlated with QUICKI (r= -0.25; P<0.0001) and adiponectin (r= -0.113; P=0.03). No correlation between ALT with: glycaemia (P=0.60), TNF-α (P=0.14) and IL-6 (P=0.82) was found.
Conclusion: Our study demonstrated that ALT was significantly correlated with markers of IR and endothelial inflammation, all of them recognized as risk parameters of pre diabetes stage. Therefore, we suggest the measurement of ALT as a marker of NAFLD should be part of the evaluation of all obesity children, mainly those with other cardiometabolic risk factors, since it could predict later development of T2DM.
Nothing to Disclose: CL, CC, AM, MA, CA, LB, RB, CAC, CEF, HG
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