Session: SUN 234-256-Bone & Calcium Metabolism: Clinical Trials & Case Series
Poster Board SUN-244
Aim:To study whether health-related quality of life (HRQoL) is impaired in PHPT and whether it improves after surgery.
Design and Method:HRQoL was assessed by the 15D instrument in 93 patients referred for surgery because of PHPT. Patients biochemically cured by surgery (n= 84, mean age 64.4 yrs (range 39-85), 67/17 F/M) were restudied at 6 mo (n= 63) and 12 mo (n= 46) and their results were compared to that of a large Finnish background population of similar age (n= 4801).
Results:Serum ionized calcium (reference range 1.15-1.30 mmol/l) and PTH (reference range 12-47 ng/l) concentrations decreased significantly after surgery (1.48 mmol/l ± 0.13 vs 1.24 ± 0.075 mmol/l and 192 ± 186 ng/l vs 27 ± 23 ng/l, respectively, both P< 0.001). At baseline, PHPT patients had significantly lower mean total 15D scores compared to the control group (0.81 ± 0.11 vs 0.87 ± 0.12, P<0.001). The patients were worse off especially in the dimensions excretion, usual activities, mental function, discomfort and symptoms, vitality and sexual activity. Six mo after surgery, mean total 15D scores had improved significantly from baseline (from 0.81 ± 0.11 to 0.86 ± 0.12 , P< 0.001). This improvement was sustained at 12 mo (0.87 ± 0.12; P< 0.001 vs baseline) and did not differ significantly from that of the control group anymore (0.87 ± 0.12 vs 0.87 ± 0.11, P=0.64). In single dimensions, significant improvement at 6 mo compared to baseline was seen in vitality, depression and sexual activity (all P< 0.001) as well as in speech, excretion, discomfort and symptoms and mental function (all P< 0.01). At 12 mo, significant improvements compared to baseline were observed in vitality, discomfort and symptoms and sexual activity (all P<0.001), in mental function and depression (both P< 0.01) and in sleeping, speech, excretion and usual activities (all P<0.05).
Conclusion: HRQoL is significantly impaired in PHPT and this impairment affects several dimensions of HRQoL. However, HRQoL significantly improves after successful surgery and the beneficial effects are sustained at 1 yr after surgery.
Nothing to Disclose: ER, RR, IH, HS, MV, CS
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