Effect of Paternal High-Fat Diet Induced Obesity on Body Composition and Voluntary Activity of Offspring

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 702-709-Obesity: Response to Interventions
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-709
Felicia Veronika Nowak*, Yizhu Zhang, Yuriy Slyvka, Alexis Zontini, John Adame and Matthew Friend
OH Univ Heritage Coll of Med, Athens, OH
Obesity is a highly prevalent metabolic disorder that predisposes those affected to develop diabetes, cardiovascular and renal disease and several types of malignancies. Offspring of obese parents are at increased risk of becoming obese and this risk is doubled if both parents are obese. Clearly, there is a paternal contribution to this phenomenon. We hypothesize that this contribution is not only behavioral, but has an inherited epigenetic component. Male C57Bl6 mice were fed either a low fat diet (LFD) or a high fat diet (HFD) for 16 weeks, then mated to females fed a LFD. Litter sizes were adjusted to 5-6 pups each. Pups were fed regular mouse chow and tested at 20 days, 6 weeks, and 6 and 12 months of age. Body composition was determined by NMR. Body (BW) and fat pad weights, including subcutaneous (SQ), gonadal (G), retroperitoneal (R), mesenteric (M), and brown (BAT) were determined uniformly. Duration of active running during a 48 hour period was also measured. Male offspring of HFD-fed fathers had a larger amount of total fat and a higher percent total body fat at 6 months than male offspring of LFD-fed males. Male offspring of HFD-fed fathers also had greater BW at 20 days and 6 weeks. Females weighed more only at 20 days. In male offspring, G and R were greater in HFD groups at 6 months; M was greater at 12 months. In females only R was greater at 6 months. In contrast SQ was less in both males and females at 12 months. G, R, and M were also less in females at 12 months. There were no differences in BAT. Surprisingly male offspring of HFD fathers at 6 weeks showed increased voluntary running as did both males and females at 6 and 12 months. The possible mechanisms for these differences are under investigation.

Nothing to Disclose: FVN, YZ, YS, AZ, JA, MF

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