The relationship between Cytotoxin-associated gene A -positive Helicobacter Pylori infection and autoimmune thyroid disease

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 432-458-Thyroid Autoimmunity
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-444
Muyesser Sayki Arslan1, Fuat Ekiz1, Zeynep Ginis1, Murat Deveci1, Oya Topaloglu1, Basak Karbek1, Esra Tutal1, Erman Cakal*1, Mustafa Sahin2, Osman Yuksel1 and Tuncay Delibasi1
1Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey, 2Ankara University Faculty of Medicine, Ankara, Turkey
Aims: Endocrine disorders thought to be associated with diabetes mellitus, autoimmune thyroid disease, dyslipidemia, obesity and osteoporosis. Expression of the cytotoxin-associated gene A (cag A) indicates the existence of a virulent H.pylori strain. The aim of this study was to determine if there is an association between CagA positivity, and thyroid autoimmunity.

Materials and Methods: This prospective study included 78 Helicobacter pylori-positive dyspeptic patients in the study group, and 50 age-, gender-, and body mass index-matched H. pylori-negative dyspeptic patients in the control group.  Gastric biopsy specimens were obtained via endoscopy and histological examination was performed for documentation of H. pylori. Fasting blood samples for thyroid function tests and thyroid autoantibodies. Thyroid ultrasonography was performed by the same expert physician (Hitachi EUB 7000 HV) and thyroid gland volume was calculated according to the ellipsoid formula.  

Results: In all, 55.1% (n = 43) of the H. pylori-positive patients were CagA positive. There wasn’t a significant difference in thyroid function test results between the study and control groups. The frequency of anti-TPO positivity and thyroid heterogeneity was significantly higher in the study group than in the control group. Additionally, thyroid volume was higher in the study group than in the controls however the difference was not significant. Also thyroid function tests, thyroid autoantibodies and thyroid volume were similar between Cag A positive and negative groups.

Conclusion: H. pylori infection including CagA strains might be a risk factor for autoimmune thyroid disease and high thyroid volume. To more clearly discern this relationship additional prospective studies with large numbers of patients diagnosed histologically are needed.

Nothing to Disclose: MS, FE, ZG, MD, OT, BK, ET, EC, MS, OY, TD

*Please take note of The Endocrine Society's News Embargo Policy at