Session: SUN 432-458-Thyroid Autoimmunity
Poster Board SUN-444
Materials and Methods: This prospective study included 78 Helicobacter pylori-positive dyspeptic patients in the study group, and 50 age-, gender-, and body mass index-matched H. pylori-negative dyspeptic patients in the control group. Gastric biopsy specimens were obtained via endoscopy and histological examination was performed for documentation of H. pylori. Fasting blood samples for thyroid function tests and thyroid autoantibodies. Thyroid ultrasonography was performed by the same expert physician (Hitachi EUB 7000 HV) and thyroid gland volume was calculated according to the ellipsoid formula.
Results: In all, 55.1% (n = 43) of the H. pylori-positive patients were CagA positive. There wasn’t a significant difference in thyroid function test results between the study and control groups. The frequency of anti-TPO positivity and thyroid heterogeneity was significantly higher in the study group than in the control group. Additionally, thyroid volume was higher in the study group than in the controls however the difference was not significant. Also thyroid function tests, thyroid autoantibodies and thyroid volume were similar between Cag A positive and negative groups.
Conclusion: H. pylori infection including CagA strains might be a risk factor for autoimmune thyroid disease and high thyroid volume. To more clearly discern this relationship additional prospective studies with large numbers of patients diagnosed histologically are needed.
Nothing to Disclose: MS, FE, ZG, MD, OT, BK, ET, EC, MS, OY, TD
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