Development of hypertension in bovine growth hormone (bGH) transgenic mice is independent of body weight

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 109-133-GHRH, GH & IGF Biology & Signaling
Bench to Bedside
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-127
Chance Michael Benner*, Adam Jara, Don Sim, Darlene E Berryman, Edward Owen List and John Joseph Kopchick
Ohio University, Athens, OH
Blood pressure maintenance is crucial in meeting the metabolic demands of body tissues.  It is influenced by both cardiac output and total resistance of peripheral blood vessels.   Growth Hormone (GH) plays an important role in blood pressure regulation by inducing cardiac development, maintaining vascular reactivity, and decreasing systemic vascular resistance.  Overproduction of GH, as exists in the pathological state of acromegaly, is associated with increased blood pressure with aging due, in part, to ventricular hypertrophy and increased vascular resistance.  GH resistant (Laron Syndrome) patients, however, have normal blood pressure despite reduced ventricular size.  Bovine GH transgenic (bGH) and GH receptor null (GHR-/-) mice represent animal models to study acromegaly and Laron syndrome, respectively. The goal of this study was to use these mouse lines to better understand how GH mediates longitudinal systolic blood pressure (SBP). Body composition and SBP were determined monthly, from 3 to 12 months of age, in GHR-/- (n=7), bGH (n=9), and littermate controls.  Results show SBP and body weight of GHR-/- mouse were significantly lower compared to all other groups at each time point.  Interestingly, the SBP of bGH mice was not significantly different from control littermates until six months of age and remained significantly elevated through 12 months of age.  This is particularly interesting since the relative body mass difference between bGH and all other groups remains constant at all time points. In conclusion, the bGH mouse develops hypertension between 5 and 6 months of age independent of their body weight.  Future work will focus on histological analysis of the kidney, heart, and vasculature of the bGH mice as well as determining serum levels of adrenal and vascular hormones.

Nothing to Disclose: CMB, AJ, DS, DEB, EOL, JJK

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: CB is supported by the provost undergraduate research fund from Ohio University. AJ is supported by a graduate GMS fellowship from the Bill and Melinda Gates Foundation and by a student enhancement award from Ohio University. EOL, DEB, and JJK are supported by funds from NIA (AG031736), NIDDK (DK075436) and by the Diabetes Institute at Ohio University. JJK also is supported the State of Ohio’s Eminent Scholar Program that includes a gift from Milton and Lawrence Goll and by the AMVETS.