Session: MON 842-862-Insulin Signaling & Action
Poster Board MON-862
Crystalline Glutathione was formulated with Ascorbic Acid crystals into a Charge Transfer Complex by a series of timed mixing processes. This Complex proved to be charge neutral, with a more stable thiol group. Therefore, the two major impediments to the use of Glutathione as a drug were removed. Transport of glutathione is by ubiquitous transporters on plasma membranes, in mitochondrial membranes and in the nuclear envelope. Our Medical-Glutathione™ speeds this transport.
Medical-glutathione™ forms a Redox Couple in solution. In Phase 1, 2a Trials in Glutathione-deficient, early HIV-positive people it has proven to be safe, charge-neutral, pure, stable, orally bioavailable with rapid absorption and intracellular distribution in timed blood samples of Peripheral Blood Mononuclear Cells (PBMC’s)starting at 30 minutes, peaking in the Area Under the Curve at 90 minutes with return to baseline at 120 minutes, followed by a second oral dose that approximately repeats the first dose AUC.
Oral repletion of intracellular glutathione is feasible and would serve to safely correct a number of the pathologic mechanisms in Diabetes, in concert with existing modalities.
Nothing to Disclose: HD
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