Session: SAT 532-553-Hyperandrogenic Disorders
Poster Board SAT-543
Overnight polysomnography was performed in 21 AA PCOS women (28 ± 1 yr, BMI 38 ± 2 kg/m2) and 21 AA controls matched for age (29 ± 1 yrs), BMI (39 ± 2 kg/m2), and OSA presence and severity. None of the participants were using hypnotics or other medications with a potential to alter sleep. Sleep recordings were visually scored in stages wake, N1, N2, N3 and REM using standard criteria. The presence of OSA was defined by an apnea-hypopnea index (AHI) > 5 events/h. Spectral analysis was used to quantify the intensity of non-REM sleep (delta activity: absolute spectral power in the 0.75 - 4 Hz band). Results are reported as mean ± SEM.
As expected, testosterone and free testosterone levels were higher in PCOS patients. One third of both control and PCOS subjects had OSA, and AHI was similar in both groups (PCOS 7 ± 1, vs controls 6 ± 2; p=0.13). No significant differences in sleep stage duration were observed between groups over the entire night. However, PCOS patients had more REM sleep than controls in the first 3 hours of sleep (26 ± 3 vs 18 ± 2 min; p=0.04). No group differences were detected in delta activity in NREM sleep.
In conclusion, African-American women with PCOS appear to have an increased REM sleep duration in the first hours of sleep. REM sleep is normally prevalent in the second half of the night. Abnormal REM sleep distribution is one of the hallmarks of sleep abnormalities observed in depression and may be related to the higher risk of mood disorders in PCOS patients. Disorders of SWS do not appear to contribute to the metabolic alterations in women with PCOS.
Nothing to Disclose: LLM, KAT, BM, ET, FC, EV, DAE
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