White blood cells levels and PCOS: direct and indirect relationship with insulin resistance, but not with hyperandogenemia

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 498-523-Female Reproductive Endocrinology & Case Reports
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-510
Olga Papalou*1, Sarantis Livadas2, Athanasios Karachalios1, Nektarios Benetatos1, Georgios Boutzios1 and Evanthia Diamanti-Kandarakis3
1Sotiria Hospital, Athens University Medical School, Athens, Greece, 2Unit of Endocrinology, Metabolism and Diabetes, Athens, Greece, 3Med Schl Univ of Athens, Athens, Greece
Background: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder, characterized by hyperandrogenism, insulin resistance and obesity. Another emerging important factor of PCOS is low grade chronic inflammation. The aim of the present study was to investigate leycocyte count in PCOS and assess its role as a possible marker of low-grade inflammation.

Methods: Two hundred and thirty six women (n=236) with PCOS (Rotterdam criteria) and 45 healthy control women were recruited. Complete anthropometrical, metabolic, hormonal and biochemical evaluation, as well as white cell count measure, was performed in the sample.

Results: In the population of women with PCOS, white blood count was significantly correlated with BMI (P<0.001), testosterone, free testosterone, SHBG (P<0.001), HOMA score (P=0.001), E2, FG score, HDL (P<0.001), TGL (P<0.001), insulin (P<0.001) and free androgen index (P= 0.01), whereas no correlation has been observed in the group of controls. Partial correlation analysis, controlling for BMI and age, revealed statistically significant correlation of WBC with SHBG, TGL and HDL in the PCOS group and no correlation in the group of controls. Multiple linear regression analysis was applied to the whole sample and showed that the main predictors of white cell count is BMI and PCOS status. Finally, in complete harmony with this finding, grouping the whole sample based on the number of the white cells, we observed that the biggest rate of women with WCC >6.000/μl has BMI> 27 kg/m2 and belongs to the PCOS group.

Conclusions: Chronic low grade inflammation and increased white cell count do occur in PCOS. Not only insulin resistance and obesity, but also hyperandrogenemia seem to significantly contribute to this inflammatory state. However, the mechanism and the clinical significance of these findings need to be further investigated.

Nothing to Disclose: OP, SL, AK, NB, GB, ED

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm