Session: SUN 498-523-Female Reproductive Endocrinology & Case Reports
Poster Board SUN-510
Methods: Two hundred and thirty six women (n=236) with PCOS (Rotterdam criteria) and 45 healthy control women were recruited. Complete anthropometrical, metabolic, hormonal and biochemical evaluation, as well as white cell count measure, was performed in the sample.
Results: In the population of women with PCOS, white blood count was significantly correlated with BMI (P<0.001), testosterone, free testosterone, SHBG (P<0.001), HOMA score (P=0.001), E2, FG score, HDL (P<0.001), TGL (P<0.001), insulin (P<0.001) and free androgen index (P= 0.01), whereas no correlation has been observed in the group of controls. Partial correlation analysis, controlling for BMI and age, revealed statistically significant correlation of WBC with SHBG, TGL and HDL in the PCOS group and no correlation in the group of controls. Multiple linear regression analysis was applied to the whole sample and showed that the main predictors of white cell count is BMI and PCOS status. Finally, in complete harmony with this finding, grouping the whole sample based on the number of the white cells, we observed that the biggest rate of women with WCC >6.000/μl has BMI> 27 kg/m2 and belongs to the PCOS group.
Conclusions: Chronic low grade inflammation and increased white cell count do occur in PCOS. Not only insulin resistance and obesity, but also hyperandrogenemia seem to significantly contribute to this inflammatory state. However, the mechanism and the clinical significance of these findings need to be further investigated.
Nothing to Disclose: OP, SL, AK, NB, GB, ED
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