FP19-3 REPRODUCTIVE PROFILE THROUGHOUT LIFE IN THE PCOS CONDITION

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: FP19-Female Reproductive Endocrinology
Basic/Clinical
Sunday, June 16, 2013: 10:45 AM-11:15 AM
Presentation Start Time: 10:55 AM
Room 102 (Moscone Center)

Poster Board SUN-499
Nicolas Crisosto*, Barbara Echiburu, Amanda Ladron de Guevara, Cristian Miranda, Manuel Maliqueo and Teresa Sir-Petermann
University of Chile, Santiago, Chile
Context: Polycystic ovary syndrome (PCOS) is a common familial endocrine-metabolic disorder. Follow up studies in PCOS patients have been previously published during reproductive age. Nevertheless, two important transition periods, peripuberty and perimenopause have not been systematically addressed. During the last 20 years we have studied PCOS patients and their daughters during different periods of life and compared them to control women. Objective: To study the reproductive profile of the PCOS condition from infancy to perimenopause. Design: 147 daughters of PCOS women (PCOSd) and 133 daughters of control women (Cd) were studied during infancy, (2 to 3 months old) childhood (4 to 7 years old) or peribuberty (8 to 16 years old). Additionally 270 adult PCOS patients and 78 control women were studied during three different periods (18 to 34; 35 to 40 and 41 to 55 years of age). In all groups, a GnRH agonist test (leuprolide acetate, 10 ug/Kg s.c.) with measurement of circulating concentrations of gonadotropins, sex steroids, sex hormone binding globulin (SHBG) and anti- Müllerian hormone (AMH) was performed. Concomitantly, ovarian volumes were determined by ultrasound. Results: During infancy and childhood the PCOSd group showed higher AMH levels with no significant differences in other parameters. During peribuberty ovarian volume, AMH and testosterone levels were significantly higher in the PCOS group.  During the 18 to 35 year old period basal testosterone, LH and AMH concentrations as well as ovarian volume were higher in the PCOS group compared to the control group. In the 35 to 40 year old group ovarian volumes, AMH and testosterone levels were higher compared to the control group. Nevertheless, LH levels were similar while FSH levels were significantly lower compared to the control group. In the 41 to 55 year old period ovarian volumes, AMH and testosterone levels were still higher but FSH and LH levels showed no significant difference compared to the control group. Within the PCOS group there was a decrease in AMH, testosterone and LH levels between the 18 to 34 and the 35 to 40 year old periods, while FSH levels do not change. Conclusions: Our results show that one of the first disturbances observed in PCOS daughters are altered AMH levels. During peribuberty the main reproductive feature added is hyperandrogenemia. In adult PCOS patients during the main reproductive period the classic pattern of high AMH and testosterone levels associated with high LH is observed. Interestingly, during the 35 to 40 year old period LH levels decrease as well as AMH and testosterone levels, while FSH levels do not change. This transitory profile during this stage may represent a favorable period in terms of reproduction that should be explored in further studies.

Nothing to Disclose: NC, BE, AL, CM, MM, TS

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: FONDECYT Grants 1071007 and 1110864