Clinical Characteristics of Bone Age Advancement in Prepubertal Children

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 596-630-Pediatric Endocrinology
Clinical
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-615
Hae Soon Kim*1, Young Ju Kim2, Hwayoung Lee2, Hye Sun Gwak3, Eun Ae Park2, Sujin Cho2, Eun Hee Ha2, Hyesook Park2 and Hye Ah Lee2
1EWHA Womans Univ Mokdong Hosp, Seoul, South Korea, 2Ewha Womans University, 3EwhaWomans University
Clinical Characteristics of Bone Age Advancement in Prepubertal Children

Hye Ah Leea, Young JuKimb, HwayoungLeec, Hye Sun Gwakd, EunAe Parke, SujinChoe, EunHee Haa, Hyesook Parka, Hae Soon Kime

aDepartment of preventive medicine, bObstetrics and Gynecology, cAnatomy,

dColleage of Pharmacy, eDepartment of Pediatrics, School of Medicine,

A, Seoul, Korea.

Purpose: It is certain that genetic factor and multiple hormones are involved in skeletal maturation. Bone age advancement in prepubertal children may lead to earlier puberty and reduction of final adult height. Our purpose was to define the clinical characteristics of bone age advancement in prepubertal children.

Subjects and Methods:During July to August 2011, we conducted a follow-up examination aged 7 to 9 children, who were part of Ewha Birth & Growth Cohort study, Seoul, Korea, which is a prospective cohort established 2001-2006. Bone age was assessed using Greulich-Pyle method. An index of BA advancement was calculated as bone age divided by chronologic age (BA/CA), and it was classified into tertiles. We applied a sex-stratified analysis for association.We assessed the relationship of bone age advancement and anthropometric characteristics, metabolic components, adrenal hormones, and sex hormones using one way analysis of variance.

Results: The study subjects comprised 200 children (106 boys, 94 girls). The mean level of BA/CA in boys was 0.97(±0.15), and in girls was 1.03(±0.14). Height z-score and weight z-score were lowest in the 1st tertile for BA/CA and highest in the 3rd tertile in both sexes. BMI z-score, body fat mass and waist circumference were significantly different between tertiles in boys, but there were no significant difference in girls. In addition, the 3rd tertile had the highest risk for overweight and obesity in boys (1st = 5.56%, 2nd = 10.42%, 3rd = 40.91%, ptrend<0.01), whereas there was no significant difference in girls. In endocrine parameters, there were significant mean difference between tertiles in terms of testosterone, DHEA, androstenedione, IGF-1, and insulin for boys, and androstenedione for girls. However, both boys and girls were not any significant difference in HOMA-IR, cholesterol and vitamin D between tertiles.

Conclusion: These results showed that obesity and increasing of adrenal hormones were related with bone age advancement in prepubertal children, especially in boys.

Acknowledgement:This work was supported by National Research Foundation of Korea Grant funded by the Korean Government (2010-0026225).

Nothing to Disclose: HSK, YJK, HL, HSG, EAP, SC, EHH, HP, HAL

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: Acknowledgement:This work was supported by National Research Foundation of Korea Grant funded by the Korean Government (2010-0026225).