Hypoglycemic effects of the chloroformic leaf extract of Carica papaya in experimental diabetic rat model

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 758-775-Beta Cells, Glucose Control & Complications
Basic/Translational
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-774
Isela Juarez-Rojop*1, Carlos Tovilla-Zarate2, Pedro Miranda-Osorio3, Deysi Bermúdez-Ocaña4, Fernando Roa-de la Fuente5, Antonia Jiménez-Santos6, Teresa Ramón-Frías3, Hidemi Aguilar-Mariscal3, Jorge L Ble-Castillo3 and Juan C Diaz-Zagoya7
1Division Academica de Ciencias de la Salud., Villahermosa, Mexico, 2División Académica Multidisciplinaria de Comalcalco. UJAT, 3Centro de Investigación, DACS, Universidad Juárez Autónoma de Tabasco, 4División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, 5Division Academica de Ciencias Basicas. UJAT, 6División Académica Multidisciplinaria de Comalcalco,UJAT, 7Univ Nacional Autonoma de Mexico, Mexico D.F., Mexico
Hypoglycemic effects of the chloroformic leaf extract of Carica papaya in experimental diabetic rat model.

Several studies have reported that some parts of the C. papaya plant exert hypoglycemic effects in both animals and humans. Recent decades have shown a surging interest in traditional plant treatment for diabetes therefore, the purpose of this study was to assess the hypoglycemic effect of the chloroformic extract of C. papaya leaves in diabetic rats. Diabetes was induced in rats by intraperitoneal administration of 60mg/kg of streptozotocin (STZ). The chloromic extract of C. papaya was administered in three different doses (31, 62, 124 mg/Kg; via oral) during 4 weeks a diabetic and non-diabetic animals. The chloroformic extract of Carica papaya (0.75 g and 1.5 g/100 mL) significantly decreased blood glucose levels in diabetic rats. It also decreased cholesterol, triacylglycerol and amino-transferases blood levels. Finally, this extract decreases the concentration of liver glycogen in diabetic rats. These data suggest that the aqueous chloromic extract of C. papaya possess hypoglycemic effect; however, high doses may induce toxicity. Its hypoglycemic effect is not completely clear, although it could be useful for support to improve the condition in diabetic patients.

Nothing to Disclose: IJ, CT, PM, DB, FR, AJ, TR, HA, JLB, JCD

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm