Session: MON 758-775-Beta Cells, Glucose Control & Complications
Poster Board MON-774
Several studies have reported that some parts of the C. papaya plant exert hypoglycemic effects in both animals and humans. Recent decades have shown a surging interest in traditional plant treatment for diabetes therefore, the purpose of this study was to assess the hypoglycemic effect of the chloroformic extract of C. papaya leaves in diabetic rats. Diabetes was induced in rats by intraperitoneal administration of 60mg/kg of streptozotocin (STZ). The chloromic extract of C. papaya was administered in three different doses (31, 62, 124 mg/Kg; via oral) during 4 weeks a diabetic and non-diabetic animals. The chloroformic extract of Carica papaya (0.75 g and 1.5 g/100 mL) significantly decreased blood glucose levels in diabetic rats. It also decreased cholesterol, triacylglycerol and amino-transferases blood levels. Finally, this extract decreases the concentration of liver glycogen in diabetic rats. These data suggest that the aqueous chloromic extract of C. papaya possess hypoglycemic effect; however, high doses may induce toxicity. Its hypoglycemic effect is not completely clear, although it could be useful for support to improve the condition in diabetic patients.
Nothing to Disclose: IJ, CT, PM, DB, FR, AJ, TR, HA, JLB, JCD
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