Session: SUN 199-233-Bone Biology
Poster Board SUN-209
Under regular diet, glucose clearance was significantly increased in mice lacking the IGF-1 receptor in osteoblasts (IGF-1R OBKO, Cre-Recombinase driven by the 2.3 kb Collagen (α)I Type I promoter) compared to control mice. Glucose clearance was overall more improved in the female than in the male group. However, with the ingestion of a high fat diet, the differences in glucose clearance were not significant between IGF-1R OBKO mice and control mice for either gender. Female lean mass but not fat mass was significantly decreased in female IGF-1R OBKO mice compared to control mice ingesting a normal diet, and the high fat diet failed to increase the female fat mass in IGF-1R OBKO. In contrast, male lean mass was not decreased in the IGF-1R OBKO mice compared to control mice after a regular diet, and the high fat diet showed an increase in the male fat mass in IGF-1R OBKO mice over control mice.
Our preliminary results suggest that the early osteoblasts may have an important role in regulating both glucose and fat metabolism. The metabolic effects of IGF-1 signaling in osteoblasts are more pronounced in the female than in the male group in a diet dependent manner. Further metabolic tests will determine whether these effects are due to changes in endocrine factors such as insulin and osteocalcin and/or to alterations in physical activity, food intake or thermogenesis.
Nothing to Disclose: MB, FC, MO, EA, YW, CT, BK, PK, DDB
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
This work is supported by a fellowship grant from the Novartis Foundation and the Janggen-Poehn Foundation awarded to Muriel Babey and by grant R01DK054793 from the National Institutes of Health awarded to Daniel D. Bikle.
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