Session: SUN 780-806-Determinants of Insulin Resistance & Associated Metabolic Disturbances
Poster Board SUN-799
Thirty healthy older men age 66 ± 6 years underwent chemical androgen ablation followed by T and/or E replacement. After baseline studies for measurement of serum hormone, glucose and insulin levels, participants were randomized into one of four groups: 1) continuation of T and E, 2) continuation of T only 3) continuation of E only or 4) discontinuation of both T and E. Repeat studies were performed 6 weeks after randomization. Changes in basal insulin levels were analyzed using an ANCOVA model that adjusted for baseline insulin and age. Preliminary data from this prospective study is being presented.
The major outcome variable being presented is changes in basal insulin levels. There was a significant difference (p=0.023) observed in change from pre- to post-intervention basal insulin levels between the groups receiving E only (estimated post-pre = -1.55, SE=1.34) versus the group receiving no hormone replacement (estimated post-pre = 3.45, SE=1.47). There was also a significant difference (p=0.042) in the change in basal insulin levels between the groups receiving E replacement with or without T replacement (estimated post-pre for with and without T: 2.58 vs. -1.55, respectively).
This unexpected finding suggests that estrogen may have independent effects on insulin sensitivity. If estrogen indeed has an independent regulatory role in this regard, this would suggest that aromatase transformation of testosterone to estrogen in men could be important in the effects of testosterone on insulin sensitivity. In addition, this would be consistent with the important role already demonstrated for estrogen on bone metabolism and with the metabolic effects observed in aromatase deficient males.
Nothing to Disclose: CCL, LJL, CKR, MAT, JC, SB, TJH
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