Session: SAT 723-745-Lipids: Fatty Liver Disease & Lipodystrophies
Poster Board SAT-742
Methods We defined chronic kidney disease (CKD) as glomerular filtration rate (GFR) <60 mL/min, estimated by the MDRD equations. Study subjects were recruited from a population of patients who visited the Health Screening Center at Kangbuk Samsung Hospital between January 2005 and December 2010 for routine medical examinations. We retrospectively assessed 130,409 participants of annual health examination during 3.15 years of follow-up.
Results The people with atherogenic dyslipidemia had higher prevalence of CKD. The subjects with high (4th) quartile of non high density lipoprotein (HDL) cholesterol had higher risk of chronic kidney disease (hazard ratio 2.52; 95% CI 1.17-5.39, p=0.017) compared to lower (1st) quartile of non HDL cholesterol independently of age, sex, baseline GFR, BMI, waist circumference, hypertension, hemoglobin A1c.
Conclusions Our findings suggest that atherogenic dyslipidemia (high quartiles of non HDL cholesterol) is associated with an increased prevalence of chronic kidney disease in healthy general populatioins. Further studies are required to evaluate whether atherogenic dyslipidemia contribute to the progression of CKD.
Nothing to Disclose: SHY, CSK, JGK, YCH, HYA, CP
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