Atherogenic dyslipidemia increased the prevalence of renal insufficiency in healthy populations

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 723-745-Lipids: Fatty Liver Disease & Lipodystrophies
Basic/Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-742
Sung Hoon Yu*1, Chul Sik Kim1, Jun Goo Kang2, You-Cheol Hwang3, Hong Yup Ahn4 and Cheolyoung Park5
1Hallym University College of Medicine, Seoul, South Korea, 2Hallym University College of Medicine, 3Kyung Hee University School of Medicine, Seoul, South Korea, 4Department of Statistics, Dongguk University-Seoul, 5School of Medicine Sungkyunkwan University
Introduction Dyslipidemia is common in general populations. A lot of studies have shown that dyslipidemia is important risk factor for the development of cardiovascular disease. A few studies suggested that dyslipidemia may contribute to accelerated development of renal insufficiency. We sought to determine the association of plasma lipids with loss of renal function and the clinical onset of mild renal insufficiency.

Methods We defined chronic kidney disease (CKD) as glomerular filtration rate (GFR) <60 mL/min, estimated by the MDRD equations. Study subjects were recruited from a population of patients who visited the Health Screening Center at Kangbuk Samsung Hospital between January 2005 and December 2010 for routine medical examinations. We retrospectively assessed 130,409 participants of annual health examination during 3.15 years of follow-up.

Results The people with atherogenic dyslipidemia had higher prevalence of CKD. The subjects with high (4th) quartile of non high density lipoprotein (HDL) cholesterol had higher risk of chronic kidney disease (hazard ratio 2.52; 95% CI 1.17-5.39, p=0.017) compared to lower (1st) quartile of non HDL cholesterol independently of age, sex, baseline GFR, BMI, waist circumference, hypertension, hemoglobin A1c.

Conclusions Our findings suggest that atherogenic dyslipidemia (high quartiles of non HDL cholesterol) is associated with an increased prevalence of chronic kidney disease in healthy general populatioins. Further studies are required to evaluate whether atherogenic dyslipidemia contribute to the progression of CKD.

Nothing to Disclose: SHY, CSK, JGK, YCH, HYA, CP

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm