Glomerular filtration rate in the context of type 2 diabetes, simulated in an interactive quantitative temporal physiological model

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 758-775-Beta Cells, Glucose Control & Complications
Basic/Translational
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-766
Steven Andrew Garan*, Shuzhang Sun, Hashroop K. Gurm, Kimberly D. Pham, Anensshiya Govinthasamy, Tiffany H. Chen, Sheba Plamthottam, Warren Freitag, Benyam Goitom, Randall White, Shivam Sachaphimukh, Behnaz Ahmed, Gizem Efe, Nabhojit Banerjee and Yoyo Tsai
University of California, Berkeley, Berkeley, CA
The glomerular filtration rate in the context of type 2 diabetes has been simulated in an interactive quantitative temporal physiological model using the Center for Research and Education in Aging Language (CREAL). CREAL is a language that can be used to describe biological systems from a macro to a molecular scale. This model displays the concentration of glucose throughout the gastrointestinal (GI) tract in relation to time. The rate of absorption of glucose through the intestinal walls and subsequent modulation of insulin and glucagon secretion rates can be graphed in relation to time as well as the utilization and depletion of glucose by the various organ systems. The glomerular response to hyperglycemia induced by type 2 diabetes is simulated and the amount of glucose excreted from the kidneys can be graphed during a selected time period. 

Nothing to Disclose: SAG, SS, HKG, KDP, AG, THC, SP, WF, BG, RW, SS, BA, GE, NB, YT

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm