Session: SUN 690-701-Obesity Pathophysiology
Poster Board SUN-693
Subjects consisted of 165 (90 male) from a longitudinal cohort of overweight/obese Latino adolescents who had at least 2 annual visits (median 3, maximum 7). The mean age was 11.2 years and mean BMI z-score was 2.04 at baseline. %BF was determined by DEXA. Total leukocyte (WBC), and absolute (NEUT), lymphocytes (LYMPH), and monocytes (MONO) were measured by routine blood leukocyte counts. Separate marginal models were built for each leukocyte measurement and were estimated by GEE. The cross-sectional and longitudinal effects of time-varying %BF were disaggregated as %BF at baseline (%BFBase) and change-from-baseline (%BFChange). Time-in-study, sex, and baseline Tanner were included as a priori covariates.
After adjusting for covariates and including significant interactions, WBC (β=.07, p<0.05) and NEUT (β=.05, p<0.05) at baseline were positively associated with %BFBase. On average, all leukocyte counts remained stable across puberty (Tanner main effect, p>0.05), although WBC increased across Tanner with increasing %BFBase (β=0.02, p<0.05). The distinct nature of the interactions between %BFChange and linear trend over Tanner (NEUT, β=-0.03, p<0.001; LYMPH, β =0.01, p<0.01; MONO, β =0.01, p<0.05), and quadratic trend over Tanner (MONO, β =-0.002, p<0.05) indicate that the positive associations between %BFChange and NEUT, MONO, and LYMPH is greatest at early, middle, and later Tanner stages, respectively.
Higher %BFBase predicts increasing WBC across puberty, whereas the strength of the positive association between %BFChange and leukocyte subtypes changes distinctly across time. These data are consistent with an inflammatory condition in obese adolescents, and that stages of adolescent development can modify the relationship between changing body composition and blood leukocytes.
Nothing to Disclose: BDK, CMT, TLA, MW, MIG
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