Session: MON 776-795-Cardiometabolic Risk & Vascular Biology
Poster Board MON-788
81 subjects were enrolled. The erythrocyte deformability was measured in terms of elongation index (EI) with microfluidic ektacytometer, RheoScan. The aggregation index (AI) was measured with RheoScan, too. All subjects were divided by 5 groups as follows: Healthy control (n=12), prediabetes (pre-DM, n=7), diabetes without vascular complications (DM-no Cx, n=24), diabetes with microvascular complications (DM-microCx, n=28) and diabetes with macrovascular complications (DM-macroCx, n=10).
A significant reduction of erythrocyte deformability was observed in DM-microCx group and DM-macroCx compared with healthy control (0.325 & 0.325 vs. 0.344, p<0.05). Also, EI was significantly decreased in the group of higher HbA1c level (a1c≥9%) compared with in the group of lower HbA1c level (a1c<7%, 0.328 vs. 0.339, p<0.05).
EI is a sensitive parameter to detect impairment of erythrocyte in diabetic process. The results in this study suggest that significant reduction in the EI may have correlation with diabetic vascular complications, and furthermore could be one of the indicators of these complications.
Nothing to Disclose: SK, CK, MKK, JH, HB, EK, TWN, SK, KRK, JSP, CWA
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