Session: MON 685-694-Mechanisms of Obesity
Poster Board MON-694
To clarify the association between adiposity and GH secretion, we investigated the relationship between pulsatile GH secretion and body weight, epididymal fat mass, circulating levels of insulin, and non-esterified free fatty acids (NEFAs). Data were obtained from male mice maintained on a standard or high fat diet. We confirm the suppression of pulsatile GH secretion following dietary induced weight gain. Correlation analyses reveals an inverse relationship between measures of pulsatile GH secretion, body weight and epididymal fat mass. We demonstrate an inverse relationship between parameters of pulsatile GH secretion and circulating levels of insulin. The secretion of GH does not change relative to circulating levels of NEFAs.
We conclude that impaired pulsatile GH secretion in the mouse occurs alongside progressive weight gain, and thus precedes the development of obesity. The close inverse relationship between circulating levels of insulin and pulsatile measures of GH secretion suggest a complementary role in sustaining balanced NEFA flux. Using transgenic and dietary induced obese mouse models, we are now investigating the role of altered GH/Insulin balance in progressive weight gain, obesity and related pathologies.
Nothing to Disclose: FJS, TX, LH, SN, JDV, MJW, CC
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