Association between BDNF polymorphism and psychiatric symptoms

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 796-817-Diabetes Genetics & Epidemiology
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-813
Min Kyung Kim*1, Jiyoon Ha1, Haeri Baek1, Sohee Kim1, Chanhee Kyung1, Youngmi Lee1, Tae Woong Noh1, Shinae Kang1, Kyung Rae Kim1, Jong Suk Park1 and Chul Woo Ahn2
1Gangnam Severance Hospital, Seoul, South Korea, 2Gangnam Severance Hospital, Seoul
The prevalence of depression in patients with diabetes mellitus(DM) is twice than in the general population. The brain-derived neurotrophic factor(BDNF) plays an important role in neurogenesis and neuro-protection. Some studies have suggested that BDNF plays an anti-diabetic role as well as its role in the psychiatric symptoms. The BDNF polymorphism is known to contribute to psychiatric illness. However, little is known about the impact of the BDNF polymorphism in DM. In this study we investigated whether the BDNF Val/66/Met polymorphism, glucose status, psychological susceptibility and resilience contribute to development of anxiety(AS) or depression symptom(DS) in newly diagnosed DM patients.

We examined biochemical factors and the BDNF polymorphism in 89 Korean DM subjects. Psychiatric symptoms were investigated by the Hospital Anxiety and Depression Scale (HADS). We analyzed stress that the patients might have from perspectives of psychological resilience and susceptibility by using resilience scale and impact of event scale(IES).

62 out of the 89 were found to be Met carriers(MC). No significant differences were found between Val/Val homozygotes(VH) group and MC group regarding age, sex, BMI and clinical factors related to glycemic control and lipid profile. HADS-anxiety, HADS-depression and IES scales such as hyperarousal, avoidance, intrusiveness and sleep problem in MC group were significantly higher than VH group(all P<0.05). HbA1c and DS showed inverse correlation (r= -0.227; P=0.035). Resilience factors such as self-efficacy, self-confidence, optimism and self-control showed inverse correlations and IES factors showed positive correlation with DS. In logistic regression analysis, DS have associations with HbA1c(OR=0.671; p=0.031) and BDNF polymorphism (OR=5.413; p=0.044) whereas hyperarousal was the only variable that is associated with AS(OR=1.386; p=0.024).

These results suggest that DS is related to presence of the Met-allele and lower HbA1c whereas AS is related to hyperarousal in newly diagnosed DM patients.

Nothing to Disclose: MKK, JH, HB, SK, CK, YL, TWN, SK, KRK, JSP, CWA

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