Session: MON 796-817-Diabetes Genetics & Epidemiology
Poster Board MON-813
We examined biochemical factors and the BDNF polymorphism in 89 Korean DM subjects. Psychiatric symptoms were investigated by the Hospital Anxiety and Depression Scale (HADS). We analyzed stress that the patients might have from perspectives of psychological resilience and susceptibility by using resilience scale and impact of event scale(IES).
62 out of the 89 were found to be Met carriers(MC). No significant differences were found between Val/Val homozygotes(VH) group and MC group regarding age, sex, BMI and clinical factors related to glycemic control and lipid profile. HADS-anxiety, HADS-depression and IES scales such as hyperarousal, avoidance, intrusiveness and sleep problem in MC group were significantly higher than VH group(all P<0.05). HbA1c and DS showed inverse correlation (r= -0.227; P=0.035). Resilience factors such as self-efficacy, self-confidence, optimism and self-control showed inverse correlations and IES factors showed positive correlation with DS. In logistic regression analysis, DS have associations with HbA1c(OR=0.671; p=0.031) and BDNF polymorphism (OR=5.413; p=0.044) whereas hyperarousal was the only variable that is associated with AS(OR=1.386; p=0.024).
These results suggest that DS is related to presence of the Met-allele and lower HbA1c whereas AS is related to hyperarousal in newly diagnosed DM patients.
Nothing to Disclose: MKK, JH, HB, SK, CK, YL, TWN, SK, KRK, JSP, CWA
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
See more of: Abstracts - Orals, Featured Poster Presentations, and Posters