Thyroid function abnormalities in term newborns from Korean mothers with autoimmune thyroid disease

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 622-631-Pediatric Endocrinology: Thyroid
Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-631
So Eun Park*1 and Sung Yeon Ahn2
1CHA medical center, CHA University, Seul,, South Korea, 2Kangwon National Univ Hosp, Chuncheon, South Korea
Background: Maternal autoimmune thyroid disease(AITD) may affect neonate’s thyroid function.

Purpose: To evaluate of thyroid function status in term newborns of mothers with autoimmune thyroid diseases retrospectively.

Methods:  Sixty-five term neonates born from 63 mothers with Hashimoto’s disease(57) or Graves’ disease(8) had a thyroid function test by measurement of serum thyroid stimulating hormone and free thyroxine between 3rd and 5th day of life. TSH receptor antibodies, thyroid peroxidase antibody, and antithyroglobulin antibodies were also measured.

Results: A total of 52.3%(34) of neonates (87.5% of neonates from Graves’ disease mothers and 47.4% of neonates from Hashimoto’s disease mothers.) revealed abnormal thyroid function tests; both increased TSH and decreased FT4 in two neonates and only decreased  FT4 in thirty two. Neonate’s thyroid antibodies were not related with abnormal thyroid function results.

Conclusions: Abnormal thyroid functions were common in early period of time of term newborns from mothers with AITD. Further studies about the change of thyroid function in a later period are needed.

Nothing to Disclose: SEP, SYA

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

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