Session: MON 842-862-Insulin Signaling & Action
Poster Board MON-860
Metabolic syndrome was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria applying the Asia-Pacific World Health Organization guidelines for WC. Total 1653 metabolic patients were enrolled in this study. BMI, WC, and serum concentration of apolipoprotein B, apolipoprotein A1, glucose, lipids (triglycerides, HDL cholesterol, and total cholesterol) and adiponectin were measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). PWV was evaluated to assess arterial stiffness.
Apolipoprotein B/A1 ratio significantly correlated with total cholesterol (γ=0.349, P<0.01), TG (γ=0.191, P<0.01), LDL-C (γ=0.271, P<0.01), HDL-C (γ= -0.309, P<0.01), adiponectin (γ= -0.142, P<0.01), HOMA-IR (γ=0.048, P=0.049), insulin (γ=0.065, P=0.048), and peripheral PWV (γ=0.043, P=0.083). Multple regression analysis showed that Apolipoprotein B/A1 ratio was significantly associated with total cholesterol (β=0.360, P<0.01), TG (β=0.175, P<0.01), HDL-C (β= -0.325, P<0.01), HOMA-IR (β=0.057, P=0.04) and adiponectin (β= -0.160, P<0.01).
Adiponectin and insulin resistance are important independent factors associated with Apolipoprotein B/A1 ratio in metabolic syndrome.
Nothing to Disclose: JSP, CWA, KRK, SK, TWN, MKK, JH, HB, CK, SK
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