OMENTIN, CHEMERIN LEVELS IN LEAN PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM AND HASHIMOTO THYROIDITIS

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 432-458-Thyroid Autoimmunity
Basic/Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-455
Bilgin Sait1, Yakup Yesil1, Safak Akin1, Duygu Yazgan Aksoy2, Kadriye Aydin3, Nese Cinar4, Jale Karakaya3 and Alper Gürlek*1
1Hacettepe University, Ankara, Turkey, 2Etlik Ihtisas Research and Training Hospital, Ankara, Turkey, 3Hacettepe University School of Medicine, Ankara, Turkey, 4Hacettepe University Medical School, Ankara, Turkey
OMENTIN, CHEMERIN LEVELS IN LEAN PATIENTS

WITH SUBCLINICAL HYPOTHYROIDISM AND

 HASHIMOTO THYROIDITIS

Bilgin Sait*, Yakup Yeşil**, Safak Akin*,Duygu Yazgan Aksoy***,

Kadriye Aydin*,Nese Cinar*, Jale Karakaya****, Alper Gürlek*

*Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Section of Endocrinology and Metabolism, Ankara, Turkey

**Hacettepe University, Faculty of Medicine, Department of Radiology

***Etlik Ihtisas Research and Training Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey

**** Hacettepe University, , Department of Biostatistics, Ankara, Turkey

BACKGROUND AND AIM:   Presence of subclinical hypothyroidism (SH) and/or Hashimoto Thyroiditis (HT) has been linked to increased cardiovascular diseases (CVD).  Change in thyroid hormone levels and/or presence of autoimmunity were accused for increased risk. Recently, the role of dysfunctional adipose tissue in CVD has become apparent. Chemerin and omentin are adipokines that are secreted from adipose tissue. Chemerin is associated with obesity, insulin resistance, metabolic syndrome whereas omentin enhances insulin action and increases after weight loss. The aim of this study was to determine the levels of chemerin, omentin in relation with carotid-intima media thickness (CIMT) (a well-established marker for CVD) in lean patients with SH and HT.

METHODS:  Fifty four patients were included in the study. Twenty eight were euthyroid (13 has HT), and 26 had SH (15 has HT). Age, sex, weight, body mass index (BMI), waist circumference (WC), thyroid stimulating hormone (TSH), CIMT, Chemerin and Omentin levels were measured. HOMA-IR was calculated accordingly.

RESULTS:  Age, weight, BMI, WC, Chemerin and Omentin levels were comparable between SH and the euthyroid group. TSH and CIMT were higher in the SH group (p<0.0001 and p=0.003 respectively). When compared according to presence of HT, all parameter were similar except higher HOMA-IR in the HT group. Subgroup analysis revealed that higher CIMT was present in the SH group independent of presence of HT, and chemerin and omentin level.

CONCLUSIONS: Chemerin and omentin levels were similar in lean patients with SH and HT. Presence of SH increased CIMT independent of HT. Our results suggest the fact that thyroid hormone changes but not the autoimmune process per se might be more influential on CVD risk.

 

Nothing to Disclose: BS, YY, SA, DY, KA, NC, JK, AG

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm