Session: FP17-Diabetes: New Diagnostic & Treatment Modalities
Room 307 (Moscone Center)
Poster Board SUN-842
39 obese, normoglycemic young Korean males were randomly assigned to control (C, n=10) or exercise group (Ex, n=29). The subjects in Ex underwent a 8-week -endurance exercise (2400Kcal/week). BMI, % body fat, waist circumference (WC), fasting plasma insulin (FPI) and glucose (FPG), total adiponectin and multimer distributions were measured. BMI, WC, % body fat, FPI, and HOMA-IR were significantly decreased in Ex (p<0.01). Unexpectedly, total adiponectin decreased significantly in Ex (p<0.01), however, HMW distribution increased from 2.27±0.55 to 15.48±8.47 (p<0.01). This increase was significantly associated with enhanced HOMA-IR (r=0.387, p=0.015), and when adjusted for BMI, WC and % body fat (r=0.357, p=0.027). These suggest that endurance exercise alleviated IR by increasing HMW.
Our study highlights the beneficial influence of endurance exercise on IR. It is noteworthy that the alteration in adiponectin multimer distributions with endurance exercise indicates a potential source for metabolic disorders in obese individuals. This study was limited to the normoglycemic obese individuals; further study with hyperglycemic individuals is warranted.
Nothing to Disclose: YSK, SK, DWY, SAK, SHB, DWH, JSP, KRK, SHS, CWA
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