Session: SUN 414-431-HPT Axis Biology
Poster Board SUN-419
Subjects and Methods: This study was conducted as a part of the Korean Longitudinal Study on Health and Aging (KLoSHA). Among 992 participants who were initially enrolled in this cohort, 411 participants who completed 5-year follow-up evaluation were analyzed in the present study. Cognitive function was evaluated using the Korean version of the consortium to establish a registry for Alzheimer’s disease assessment battery (CERAD-K), the frontal assessment battery (FAB), the revised Hasegawa dementia scale (HDS-R), and digit-span test (DST). Anthropometric and other metabolic parameter including thyroid function were also evaluated.
Results: In 325 subjects with normal thyroid function at baseline evaluation, none of evaluated cognitive domains were associated with free thyroxine (fT4) and thyroid stimulating hormone (TSH) levels at a single time-point (baseline and follow-up). The change of fT4 and TSH between baseline and follow-up were not associated with cognitive function in this group. In 68 subjects with SCH at baseline, none of cognitive domains were independently associated with fT4 or TSH at a single time point. However, the change in TSH (ΔTSH) was associated with all investigated cognitive domains except one domain of CERAD-K (constructional recall test) and FAB in this group. Moreover, 3 domains of CERAD-K (mini-mental state examination [MMSE], modified Boston naming test, and word list memory test), HDS-R, and DST were independently associated with ΔTSH after adjustment for age, education, depression, chronic illness, serum glucose, and serum vitamin B12. The increase TSH was associated with cognitive dysfunction in subjects with SCH.
Conclusion: In SCH, the decrease in thyroid function, rather than the thyroid function at a single time-point is a more important risk factor for the cognitive dysfunction in Korean elderly subjects. This result supports the need of thyroid hormone replacement in elderly subjects with SCH.
Nothing to Disclose: JHM, THK, THK, HC, SWC, KWK, YJP, KHY, KWK, DJP, HCJ
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