More rapid biological action of insulin aspart by needle-free Jet Injection

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 786-805-Diabetes & Obesity Therapeutics
Bench to Bedside
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-792
Wonjin Kim*1, Cheol Ryong Ku1, Dong Yeob Shin1, Jae Won Hong2, Ki Chang Nam1, Young-Deuk Song3 and Eun Jig Lee1
1Yonsei University College of Medicine, Seoul, South Korea, 2Yonsei Univ College of Med, Seoul, South Korea, 3NHIS Ilsan Hospital, South Korea
Objective: Administration of insulin by jet injection is an alternative to conventional method using syringes or insulin pens. Jet injection has many advantages including high velocity of drug delivery and large area of dispensing. However, changes of pharmacodynamics and pharmacokinetics so far have been poorly studied. This study compared the pharmacologic profile of insulin aspart administered by jet injection to that of same insulin injected by conventional insulin pen.

Research Design and Methods: This study was double-blind, double-dummy, and cross over study design. Euglycemic hyperinsulemic glucose clamp tests were conducted in 20 healthy volunteers after subcutaneous administration of 0.2 units/kg of insulin aspart, using conventional insulin pen and newly developed device of jet injection. Primary endpoint was time to maximal glucose infusion rate (GIR), corresponding to the time until the maximal glucose-lowering effect of insulin. Secondary endpoints were maximal GIR, maximal insulin concentration, and the time to maximal insulin concentration.

Results: The mean age of 20 enrolled volunteers (Male 12, Female 8) was 27.2 ± 6.6 years old and BMI was 23.0 ± 2.2 kg/m2. All the profiles of primary and secondary endpoints were significantly improved when the insulin aspart was injected by jet device. The time to maximal GIR was shorter and maximal GIR was increased when insulin was injected with the jet device compared with conventional pen administration (120.25 ± 64.25 min vs. 136.25 ± 54.29 min, and 11.83 ± 3.90 mg/kg/min vs. 10.27 ± 4.30 mg/kg/min, both P < 0.0001). Furthermore, the time to peak insulin concentration was significantly reduced and peak insulin concentrations were increased when insulin was administered by jet injection compared with conventional pen injection (36±16.06 vs. 68±34.43 min, 164.3 ± 82.86 mIU/L vs. 105.45 ± 43.29 mIU/L, both P < 0.0001).

Conclusions: Jet injection improved pharmacokinetic and pharmacodynamic profile of insulin aspart. Administration of insulin via jet injection might be more helpful in controlling the acute hyperglycemia in patients with diabetes than conventional method.

Nothing to Disclose: WK, CRK, DYS, JWH, KCN, YDS, EJL

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