Session: SAT 786-805-Diabetes & Obesity Therapeutics
Bench to Bedside
Poster Board SAT-792
Research Design and Methods: This study was double-blind, double-dummy, and cross over study design. Euglycemic hyperinsulemic glucose clamp tests were conducted in 20 healthy volunteers after subcutaneous administration of 0.2 units/kg of insulin aspart, using conventional insulin pen and newly developed device of jet injection. Primary endpoint was time to maximal glucose infusion rate (GIR), corresponding to the time until the maximal glucose-lowering effect of insulin. Secondary endpoints were maximal GIR, maximal insulin concentration, and the time to maximal insulin concentration.
Results: The mean age of 20 enrolled volunteers (Male 12, Female 8) was 27.2 ± 6.6 years old and BMI was 23.0 ± 2.2 kg/m2. All the profiles of primary and secondary endpoints were significantly improved when the insulin aspart was injected by jet device. The time to maximal GIR was shorter and maximal GIR was increased when insulin was injected with the jet device compared with conventional pen administration (120.25 ± 64.25 min vs. 136.25 ± 54.29 min, and 11.83 ± 3.90 mg/kg/min vs. 10.27 ± 4.30 mg/kg/min, both P < 0.0001). Furthermore, the time to peak insulin concentration was significantly reduced and peak insulin concentrations were increased when insulin was administered by jet injection compared with conventional pen injection (36±16.06 vs. 68±34.43 min, 164.3 ± 82.86 mIU/L vs. 105.45 ± 43.29 mIU/L, both P < 0.0001).
Conclusions: Jet injection improved pharmacokinetic and pharmacodynamic profile of insulin aspart. Administration of insulin via jet injection might be more helpful in controlling the acute hyperglycemia in patients with diabetes than conventional method.
Nothing to Disclose: WK, CRK, DYS, JWH, KCN, YDS, EJL
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