SCLEROSING MUCOEPIDERMOID CARCINOMA WITH EOSINOPHILIA OF THE THYROID GLAND: CASE REPORT AND REVIEW OF LITERATURE

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 429-448-Thyroid Neoplasia & Case Reports
Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-444
Kelly M Ferro*, Ricardo A Guerra, Gil L P Afonso, Mariana R N Couto, Daniel D R Paulo, Evandro S Portes, Thiago L Bueno, Olivia C G Oliveira and Thiago S Marocco
Hospital do Servidor Publico Estadual de Sao Paulo
Background: Mucoepidermoid carcinoma is usually found in the salivary glands, breast, pancreas and digestive tract, however thyroid gland involvement is uncommon.

Clinical Case: A 52-year-old woman presented with progressive neck mass and dyspnea since the last 7 months. She evolved with tracheal compression and underwent total thyroidectomy. Pathologically showed SMECE and lymphocytic thyroiditis and 5 of 5 positive lymph nodes. By immunohistochemistry, cells were positive for Cytokeratin 19 and p-67 but negative for thyroglobulin, TTF-1 and calcitonin.

Two months later, she presented with multiple atypical lymph nodes bilaterally in levels II, III, IV and supraclavicular fossa without involvement of the salivary gland. Measurement of thyroglobulin in fine needle aspirates of lymph nodes was negative. The patient underwent incomplete neck dissection, including level IV and V. Operative findings included 23 lymph nodes positive for metastasis. Postoperative chemotherapy (Cisplatin and Adriamycin) and radiotherapy was administered. She's clinically stable for 8 months.

Conclusion: Fewer than 40 cases have been described in the literature. SMECE is more common in women and association with Hashimoto thyroiditis is reported. Most of these patients have a relatively indolent course, however aggressive behaviour with extrathyroidal extension or distant metastases have been noted in some cases. This study aims to report the finding of an extremely rare tumor of the thyroid.

Nothing to Disclose: KMF, RAG, GLPA, MRNC, DDRP, ESP, TLB, OCGO, TSM

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm