SERUM PTH BUT NOT VITAMIN D PREDICTS SEVERITY OF CORONARY ATHEROSCLEROSIS

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 257-280-Disorders of Vitamin D Metabolism & Action
Basic/Translational
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-280
Kadriye Aydin*1, Duygu Yazgan Aksoy2, Ugur Canpolat1, Safak Akin1, Nese Cinar1, Jale Karakaya1, Fatma Ucar3, Levent Sahiner1, Kudret Aytemir1 and Alper Gurlek1
1Hacettepe University School of Medicine, Ankara, Turkey, 2Etlik Ihtisas Research and Training Haspital, Ankara, Turkey, 3Etlik Ihtisas Research and Training Hospital, Ankara, Turkey
Background: Vitamin D (VitD) deficiency is known to be associated with cardiovascular disease but the causality between cardiovascular disease and VitD deficiency remains controversial.

Design and Methods: Seventy nine patients who underwent coronary angiography (CAG) consequently during late winter to early summer were included in the study. Patients were categorized into three groups according to CAG findings: normal coronary arteries, nonsignificant coronary artery disease (CAD) and significant CAD. Gensini score was calculated for assessment of severity of coronary atherosclerosis. Serum vitD levels, parathormon (PTH) levels, glucose metabolism parameters including homeostasis model assessment of insulin resistance (HOMA-IR), lipid parameters were measured and analyzed for the relation with severity of coronary atherosclerosis.  

Results:  Gensini scores were significantly higher in the group with significant CAD  than the scores of the group with nonsignificant CAD and both groups had higher scores than the normal group as being consistent with the degree of the atherosclerosis. However, study parameters including vitD, PTH, HOMA-IR except total and LDL cholesterol were similar between groups. In patients with significant CAD, gensini score was found to be correlated with HOMA-IR (p=0.015, r=0.408). In the multiple regression model including gender, age, HOMA-IR,  vitD, PTH, current cigarette smoking, hypertension, HDL-cholesterol and presence of plaque in coronaries; age, presence of plaque and PTH levels were detected to be the predictors of severity of  coronary atherosclerosis reflected by Gensini score.

Conclusions: In our study,  vitD was not associated with the severity of the coronary atherosclerosis, however PTH was detected to be one of the predictors of severity of CAD. Vitamin D effects cardiovascular system via elevation of PTH secretion. Reversal of severity of atherosclerosis after vitamin D supplementation together with the decrease in PTH levels would likely strengthen the indirect role of PTH in the era of vitamin D deficiency.

Nothing to Disclose: KA, DYA, UC, SA, NC, JK, FU, LS, KA, AG

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

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