Session: SUN 257-280-Disorders of Vitamin D Metabolism & Action
Poster Board SUN-257
Methods: Two independent cohorts of the Longitudinal Aging Study Amsterdam, which is a random sample of the Dutch older population, were used. Study participants were aged 65-88 years in the first cohort (1995/1996, n=1237) and 55-65 years in the second cohort (2002/2003, n=725). Participants were asked to answer questions on six major activities of daily life: climbing stairs, dressing and undressing oneself, getting up and sitting down in a chair, cutting one’s own toenails, walking five minutes outdoors without resting, and using own or public transport. Participants were divided into two groups: no limitations and one or more limitations. An increase in functional limitations in three years was defined as having at least two more limitations than at baseline. Multiple logistic regression was used to asses whether 25-hydroxyvitamin D (25(OH)D) was associated with functional limitations and with an increase in three years.
Results: In the first cohort 56.0% and in the second cohort 30.1% of the participants had at least one limitation. An increase was observed in 15% of the first and 6% of the second cohort. Vitamin D deficiency (25(OH)D<50 nmol/L) was associated with functional limitations as compared to the reference group (25(OH)D ≥75 nmol/L) after adjustment for potential confounders (odds ratio (OR) 1.7 (95% confidence interval 1.2-2.5) in the first cohort and OR 2.1 (1.2-3.5) in the second cohort). In the first cohort, vitamin D deficiency predicted an increase in functional limitations (OR 2.0 (1.1-3.5) for participants with 25(OH)D<50 nmol/L compared with the reference group after adjustment for confounders. In the second cohort, no statistically significant association between 25(OH)D and an increase in functional limitations was observed (OR 0.8 (0.3-1.9)).
Conclusion: 25(OH)D concentrations below 50 nmol/L were associated with more functional limitations in individuals aged 55-65 years and in individuals aged 65 years and older compared with 25(OH)D >75 nmol/L, and predicted an increase in functional limitations in three years in persons aged 65 years and older.
Nothing to Disclose: ES, NMV, RTD, PL
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