Session: OR37-Pediatric Endocrinology: HPG Axis Disorders
Room 102 (Moscone Center)
Objective: To investigate the associations between genetic polymorphisms (FSHB and FSHR) and serum levels of FSH, AMH, and age at pubertal onset.
Design and Setting: We examined 78 healthy girls twize year for 5 years; median age at baseline 9.3 years. Hormone levels were measured by immunoassays and DNA was isolated from blood and genotyped by restriction fragment length polymorphism (RFLP) of PCR-amplified regions.
Results: Carriers of FSHB GG+FSHR AA had higher FSH prior to pubertal onset (median 2.2 vs. 1.5 IU/L, p=0.05) and lower AMH (13.8 vs. 19.4 pmol/L, p=0.04) compared with carriers of other genotypes. In crude analysis, girls with FSHB GG+FSHR AA entered puberty earlier; 9.7 vs. 10.6 years (p=0.03). However, the difference was no longer statistical significant after conservative probit analysis including interval-, right- and left-censored data.
Conclusions: The combined effect of FSHB GG+FSHR AA may potentiate the FSH-pathway, which increases FSH, reduces AMH, and possibly accelerates pubertal onset. Common variations in genes that regulate follicle growth, may affect AMH levels independently from the number of resting primordial follicles.
Disclosure: RAA: Consultant, Beckman-Coulter. Nothing to Disclose: CPH, LA, KS, AM, MGM, KMM, JHP, KA, ERDM, AJ
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